Schampel Andrea, Kuerten Stefanie
Institute of Anatomy and Cell Biology, University of Würzburg, Würzburg 97070, Germany.
Institute of Anatomy and Cell Biology, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen 91054, Germany.
Cells. 2017 Nov 15;6(4):43. doi: 10.3390/cells6040043.
Voltage-gated calcium channels (VGCCs) are widely distributed within the central nervous system (CNS) and presumed to play an important role in the pathophysiology of a broad spectrum of CNS disorders including Alzheimer's and Parkinson's disease as well as multiple sclerosis. Several calcium channel blockers have been in clinical practice for many years so that their toxicity and side effects are well studied. However, these drugs are primarily used for the treatment of cardiovascular diseases and most if not all effects on brain functions are secondary to peripheral effects on blood pressure and circulation. While the use of calcium channel antagonists for the treatment of CNS diseases therefore still heavily depends on the development of novel strategies to specifically target different channels and channel subunits, this review is meant to provide an impulse to further emphasize the importance of future research towards this goal.
电压门控钙通道（VGCCs）广泛分布于中枢神经系统（CNS）内，据推测在包括阿尔茨海默病、帕金森病以及多发性硬化症在内的多种中枢神经系统疾病的病理生理学中发挥重要作用。几种钙通道阻滞剂已在临床实践中应用多年，因此对其毒性和副作用已有充分研究。然而，这些药物主要用于治疗心血管疾病，对脑功能的影响（即使不是全部，也是大部分）继发于对血压和循环的外周作用。因此，使用钙通道拮抗剂治疗中枢神经系统疾病仍严重依赖于开发针对不同通道和通道亚基的新型策略，本综述旨在提供一种推动力，以进一步强调朝着这一目标开展未来研究的重要性。
