Farris Patricia K, Rogers Nicole, McMichael Amy, Kogan Sophia
J Drugs Dermatol. 2017 Nov 1;16(11):s141-s148.
Hair loss is a complicated problem that causes significant concern for those who are affected. Patients seeking medical treatment have limited options that include topical minoxidil and oral finasteride. While these treatments are backed by long term clinical use and research outcomes, many patients find topical minoxidil difficult to incorporate into their daily routine and some are concerned with the side effects associated with finasteride. In the office setting, patients may be treated with more invasive procedures such as platelet-rich plasma injections (PRP) and hair transplantation, treatments that often must be repeated and can lead to a costly investment. Consumers are increasingly interested in natural treatments for hair loss. Many turn to basic supplements only to be disappointed when they fail to deliver due to lack of standardization and efficacy. In this paper we review the benefits of a nutraceutical containing a specific blend of highly purified, standardized, bio-optimized, and bioavailable botanical extracts to treat hair loss. These phytoactives were selected because of their diverse multi-modal biologic activity against inflammation, DHT, stress mediators, oxidative damage, and intermediary signaling cascades. This supplement represents a paradigm shift as it addresses not only the factors that trigger hair loss but the downstream mediators of inflammation as well. Multi-center clinical studies are currently underway to confirm the efficacy and benefits of this unique nutraceutical.
J Drugs Dermatol. 2017;16(11 Suppl):s141-148.
.脱发是一个复杂的问题,令受其影响的人深感担忧。寻求治疗的患者选择有限,包括外用米诺地尔和口服非那雄胺。虽然这些治疗方法有长期临床应用和研究结果的支持,但许多患者发现外用米诺地尔难以融入日常生活,还有一些人担心非那雄胺的副作用。在诊所环境中,患者可能会接受更具侵入性的治疗,如富血小板血浆注射(PRP)和植发,这些治疗通常需要重复进行,而且可能导致高昂的费用。消费者对脱发的自然疗法越来越感兴趣。许多人求助于基本的补充剂,但由于缺乏标准化和疗效而未能达到预期效果,这让他们感到失望。在本文中,我们综述了一种营养保健品的益处,该营养保健品含有特定混合的高度纯化、标准化、生物优化且生物可利用的植物提取物,用于治疗脱发。选择这些植物活性成分是因为它们对炎症、双氢睾酮、应激介质、氧化损伤和中间信号级联具有多种不同的生物活性。这种补充剂代表了一种范式转变,因为它不仅解决了引发脱发的因素,还解决了炎症的下游介质问题。目前正在进行多中心临床研究,以确认这种独特营养保健品的疗效和益处。
《皮肤药物学杂志》2017年;16(11增刊):s141 - 148。