Department of Pharmacognosy, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Department of Pharmaceutical Chemistry, University of Medicine and Pharmacy "Victor Babes", Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania.
Curr Drug Targets. 2018;19(7):841-853. doi: 10.2174/1389450118666171109150731.
Isoflavones are natural compounds belonging to the class of isoflavonoids, molecules with a chemical structure based on the 3-phenyl chromen-4-one backbone. As a particular element, the isoflavones are also called phytoestrogens, due to the structural similarity with 17-β estradiol, the primary female sex hormone, presenting both estrogen-agonist and estrogen-antagonist properties. This class of secondary plant metabolites has been extensively reported in the literature for a wide range of therapeutic activities including antioxidant, chemopreventive, anti-inflammatory, antiallergic, antibacterial, and cardio preventive effects.
To sum up the latest information regarding the main isoflavones found in dietary sources as natural anti-inflammatory agents.
The review updates with the recent research about genistein, daidzein, glycitein, biochanin A, formononetin and equol as anti-inflammatory phytocompounds. As a particular element, the implications of these isoflavones in the link between inflammation and angiogenesis are also discussed.
The review concludes that the main isoflavones in dietary sources display in vitro and/or in vivo anti inflammatory potential by activating various biochemical and molecular mechanisms. The depicted findings translated into practical aspects strengthen the idea that the isoflavones genistein, daidzein, glycitein, biochanin A, formononetin and equol can be used in various inflammation based diseases as an alternative source for classical medication and that consummation of foods rich in isoflavones may represent prerequisite use in order to prevent the evolution of inflammation based diseases.
异黄酮是天然化合物，属于异黄酮类，其分子结构基于 3-苯基色原酮-4-酮骨架。作为一个特殊的元素，异黄酮也被称为植物雌激素，由于与 17-β 雌二醇（主要的女性性激素）的结构相似，具有雌激素激动剂和雌激素拮抗剂的特性。这类次级植物代谢物在文献中被广泛报道具有广泛的治疗活性，包括抗氧化、化学预防、抗炎、抗变态反应、抗菌和心脏预防作用。
总结主要异黄酮在饮食来源中作为天然抗炎剂的最新信息。
综述更新了关于饮食来源中的染料木黄酮、大豆苷元、大豆苷、大豆黄素、芒柄花素和雌马酚等主要异黄酮作为抗炎植物化合物的最新研究。作为一个特殊的元素，还讨论了这些异黄酮在炎症与血管生成之间联系的意义。
综述得出结论，饮食来源中的主要异黄酮通过激活各种生化和分子机制，在体外和/或体内显示出抗炎潜力。这些研究结果转化为实际方面，进一步加强了这样一种观点，即染料木黄酮、大豆苷元、大豆苷、大豆黄素、芒柄花素和雌马酚可以作为经典药物的替代来源，用于各种炎症性疾病，并且大量摄入富含异黄酮的食物可能代表着预防炎症性疾病发展的必要手段。
