Department of Infectious Diseases, Tianjin Medical University General Hospital, Tianjin, China.
Library, Tianjin Medical University, Tianjin, China.
J Neurol Neurosurg Psychiatry. 2018 Apr;89(4):382-388. doi: 10.1136/jnnp-2017-316176. Epub 2017 Nov 15.
Higher docosahexaenoic acid (DHA) intake is inversely correlated with relative risk of Alzheimer's disease. The potential benefits of DHA supplementation in people with mild cognitive impairment (MCI) have not been fully examined.
Our study aimed to assess the effect of a 24-month DHA supplementation on cognitive function and amyloid beta (Aβ)-mediated autophagy in elderly subjects with MCI.
This was a randomised, double-blind, placebo-controlled trial in Tianjin, China. A total of 240 individuals with MCI were identified and randomly divided into intervention (DHA 2 g/day, n=120) and control (corn oil as placebo, n=120) groups. Cognitive function and blood Aβ-related biomarkers were measured at baseline, 6, 12, 18 and 24 months. Data were analysed using generalised estimating equation.
A total of 217 participants (DHA: 109, placebo: 108) completed the trial. During the follow-up, scores of full-scale IQ, verbal IQ and subdomains of information and digit span were significantly higher in the intervention group than the convention group (p<0.05). In the intervention group, blood Aβ-42 level and expression of Aβ protein precursor mRNA were decreased (p<0.05), while Beclin-1 and LC3-II levels and expression of LC3-II mRNA were increased (p<0.05).
Daily oral DHA supplementation (2 g/day) for 24 months may improve cognitive function and change blood biomarker-related Aβ-mediated autophagy in people with MCI. Larger longer-term confirmatory studies are warranted.
ChiCTR-IOR-15006058.
二十二碳六烯酸（DHA）摄入量较高与阿尔茨海默病的相对风险呈负相关。DHA 补充剂对轻度认知障碍（MCI）患者的潜在益处尚未得到充分研究。
我们的研究旨在评估 24 个月 DHA 补充对老年 MCI 患者认知功能和淀粉样β（Aβ）介导的自噬的影响。
这是在中国天津进行的一项随机、双盲、安慰剂对照试验。共纳入 240 名 MCI 患者，随机分为干预组（DHA 2 g/天，n=120）和对照组（玉米油作为安慰剂，n=120）。在基线、6、12、18 和 24 个月时测量认知功能和血液 Aβ 相关生物标志物。使用广义估计方程分析数据。
共有 217 名参与者（DHA：109 名，安慰剂：108 名）完成了试验。在随访期间，干预组的全量表智商、言语智商和信息和数字跨度子域的评分明显高于对照组（p<0.05）。在干预组中，血液 Aβ-42 水平和 Aβ 蛋白前体 mRNA 的表达降低（p<0.05），而 Beclin-1 和 LC3-II 水平以及 LC3-II mRNA 的表达增加（p<0.05）。
每日口服 DHA 补充剂（2 g/天）24 个月可能改善 MCI 患者的认知功能，并改变与血液生物标志物相关的 Aβ 介导的自噬。需要更大规模和更长时间的验证性研究。
ChiCTR-IOR-15006058。
