Protective Effect of against Aluminum Chloride-induced Neurotoxicity in Swiss Albino Mice.

BACKGROUND

Aluminum chloride (AlCl) is a known potent environmental neurotoxin causing progressive neurodegenerative changes in the brain. The herb is commonly known as "Rasana" and used as a nerve tonic in neuroinflammatory conditions in Indian system of medicine.

OBJECTIVE

To evaluate the neuroprotective activity of hydroalcoholic extract of in chronic AlCl-induced neurotoxicity in Swiss albino mice.

MATERIALS AND METHODS

Albino mice were categorized into four different groups; Group 1served as vehicle control, Group 2 mice were administered with AlCl, 40 mg/kg body weight by intraperitoneal route for 45 consecutive days. Groups 3 and 4 mice were administered with AlCl, 40 mg/kg body weight intraperitoneal for 45 consecutive days along with hydroalcoholic extract of at 200 and 400 mg/kg body weight.

RESULTS

Chronic administration of AlCl resulted in behavioral deficits, triggered lipid peroxidation, increased acetylcholinesterase (AChE) activity, and histological alterations. Co-administration of hydroalcoholic extract of attenuated many of the AlCl-induced alterations such as behavioral, lipid peroxidation, AChE, and histological changes of brain tissue.

CONCLUSION

The results of the present study have demonstrated the protective role of hydroalcoholic extract of against AlCl-induced neurotoxicity in Swiss albino mice. The neuroprotective efficacy of can help reduce the symptoms caused by toxic protein aggregates in several degenerative diseases.

SUMMARY

The hydro alcoholic extract of showed neuroprotective activity in albino mice against AlCl toxicityThe benefits of against AlCl toxicity includes reduced lipid peroxidation and acetylcholine esterase activity with improved behavioral functionsThe hydro alcoholic extract of rendered protection against AlCl in forebrain, midbrain, cerebellum and hippocampusTherefore holds pharmacological potentials for treating diseases associated with neuronal toxicity. HAPL: Hydro alcoholic extract of ; CAT: Catalase; GSH-Px: Glutathione peroxidase; SOD: Superoxide dismutase; TBARS: Thio-barbituric acid reactive substances; MDA: Malondialdehyde; AChE: Acetylcholine esterase; AOT: Acute oral toxicity; CNS: Central nervous system; HO: Hydrogen peroxide; ML: molecular layer; GL: granular layer; MC: microcytic changes; BV: blood vessels; DG: dentate gyrus; PC: pyramidal cells; LD: Lethal dose; ANOVA: Analysis of variance; SEM: Standard error of mean; PCL: Pyramidal cell layer; OCL: Outer granular layer; BV: blood vessels; PM: Pia mater.