College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China.
Dalton Trans. 2017 Dec 21;46(47):16446-16454. doi: 10.1039/c7dt03242k. Epub 2017 Nov 16.
The single crystals of two novel mixed-ligand copper(ii)-based complexes were obtained and characterized. These complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins FAK, Akt and Erk1/2 or their phosphorylated proteins p-FAK, p-Akt, and p-Erk1/2 downstream of the VEGF/VEGFR2 signaling pathway.
两种新型混合配体铜（II）基配合物的单晶已被获得并进行了表征。这些配合物可以通过下调 VEGF/VEGFR2 信号通路下游的重要蛋白 FAK、Akt 和 Erk1/2 或其磷酸化蛋白 p-FAK、p-Akt 和 p-Erk1/2 的表达，显著诱导细胞凋亡、抑制增殖、抑制迁移和转移，并抑制血管生成，从而抑制宫颈癌的生长。
