College of Pharmacy, Guilin Medical University, Guangxi Guilin, 541004, China.
Dalton Trans. 2020 May 14;49(18):6043-6055. doi: 10.1039/d0dt00380h. Epub 2020 Apr 22.
The single crystals of two novel copper(ii)-based complexes containing l-methioninol-derived Schiff bases were obtained and characterized. The nanoparticles of these complexes were prepared and their cellular uptake was measured in MDA-MB-231 cells and HUVECs. It was found that these complexes could remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis and the growth of triple-negative breast cancer derived from MDA-MB-231 cells in vitro. Meanwhile, these complexes exhibit anticancer and antiangiogenic functions by activating the important protein molecules VEGFR2, FAK, AKT and Erk1/2 or their phosphorylated molecules p-VEGFR2, p-FAK, p-AKT, and p-Erk1/2 in the VEGF/VEGFR2 signaling pathway, collapsing the mitochondrial membrane potential, and damaging the level of reactive oxygen species.
两种新型含 l-甲硫氨酸衍生席夫碱的铜（ii）配合物的单晶已被获得并进行了表征。这些配合物的纳米颗粒已被制备，并在 MDA-MB-231 细胞和 HUVECs 中测量了它们的细胞摄取。结果发现，这些配合物可以显著诱导细胞凋亡，抑制增殖，抑制迁移和转移，以及抑制血管生成和体外来源于 MDA-MB-231 细胞的三阴性乳腺癌的生长。同时，这些配合物通过激活 VEGF/VEGFR2 信号通路中的重要蛋白分子 VEGFR2、FAK、AKT 和 Erk1/2 或它们的磷酸化分子 p-VEGFR2、p-FAK、p-AKT 和 p-Erk1/2，以及破坏线粒体膜电位和损伤活性氧水平，发挥抗癌和抗血管生成作用。
