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[采用FLOCSAT概念进行复杂关节重建与关节移植——规划与手术实施]

[Complex joint reconstruction and joint transplantation with the FLOCSAT concept-planning and surgical implementation].

作者信息

Krettek C, Clausen J-D, Neunaber C

机构信息

Unfallchirurgische Klinik, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

Unfallchirurgische Klinik, Labor für Muskulo-Skelettales Trauma & Regenerative Therapien, Medizinische Hochschule Hannover (MHH), Hannover, Deutschland.

出版信息

Unfallchirurg. 2017 Nov;120(11):950-960. doi: 10.1007/s00113-017-0429-8.

DOI:10.1007/s00113-017-0429-8
PMID:29143065
Abstract

Cartilage defects in adult patients are so far incurable. Fresh osteochondral allograft (OCA) transplantation is based on the insertion of mature, living, mechanically sound hyaline cartilage into an osteochondral defect where it undergoes osseointegration. Intact hyaline cartilage of OCA does not cause immune reactions in the recipient. Many reports show that small OCA have good osseointegration and show good long-term results. These observations have been incorporated into the development of the fresh large (> 10 cm) osteochondral shell allograft transplantation (FLOCSAT) concept, which is based on the following principles: 1) the thickness of the osseous layer should be kept as thin as possible (target < 6-8 mm) so that the transplant remains stable and fixable. This results in reduced segments of vascularization, simplified ossification and reduced immunogenic bone volume. 2) The bone surface is processed and enlarged (oscillating saw: pie crust technique, drill holes) and areas of sclerosis are simultaneously broken off. 3) Cell reduction and washing out of the bony layer with a pulsatile jet lavage. 4) Prevention of impaction and dessication: cartilage with its living chondrocytes are very sensitive to mechanical contusion and dessication. When introducing the transplant, the tissue must therefore be continually moistened and the pressure acting on the cartilage must be controlled. 5) Stable fixation: extensive uniplanar osteochondral transplants cannot be inserted by the press-fit method; therefore, fixation is carried out with small implants. In this publication we demonstrate how severe and complex posttraumatic or degenerative delayed problems can be solved using FLOCSAT.

摘要

目前,成年患者的软骨缺损无法治愈。新鲜骨软骨异体移植(OCA)是将成熟、有活力且力学性能良好的透明软骨植入骨软骨缺损处,使其发生骨整合。OCA完整的透明软骨不会在受者体内引发免疫反应。许多报告显示,小型OCA具有良好的骨整合效果且长期效果良好。这些观察结果已被纳入新鲜大型(>10厘米)骨软骨壳异体移植(FLOCSAT)概念的发展中,该概念基于以下原则:1)骨层厚度应尽可能保持薄(目标<6 - 8毫米),以便移植体保持稳定且可固定。这会减少血管化节段,简化骨化过程并减少免疫原性骨体积。2)对骨表面进行处理并扩大(摆动锯:酥皮技术、钻孔),同时去除硬化区域。3)通过脉动喷射冲洗减少骨层细胞并冲洗掉骨层。4)防止撞击和干燥:带有活软骨细胞的软骨对机械挫伤和干燥非常敏感。因此,在植入移植体时,组织必须持续保持湿润,并且必须控制作用在软骨上的压力。5)稳定固定:大面积的单平面骨软骨移植体不能通过压配方法植入;因此,使用小型植入物进行固定。在本出版物中,我们展示了如何使用FLOCSAT解决严重且复杂的创伤后或退行性延迟问题。

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本文引用的文献

1
[Partial and complete joint transplantation with fresh osteochondral allografts-the FLOCSAT concept].[新鲜同种异体骨软骨移植的部分和全关节移植——FLOCSAT概念]
Unfallchirurg. 2017 Nov;120(11):932-949. doi: 10.1007/s00113-017-0426-y.
2
Two-stage late reconstruction with a fresh large osteochondral shell allograft transplantation (FLOCSAT) for a large ostechondral defect in a non-union after a lateral tibia plateau fracture 2-year follow up.采用新鲜大段骨软骨壳同种异体移植(FLOCSAT)进行两阶段晚期重建治疗胫骨外侧平台骨折不愈合后出现的大段骨软骨缺损:2年随访结果
Injury. 2017 Jul;48(7):1309-1318. doi: 10.1016/j.injury.2017.05.010. Epub 2017 May 17.
3
Articular Cartilage Injury and Potential Remedies.
关节软骨损伤与潜在治疗方法。
J Orthop Trauma. 2015 Dec;29 Suppl 12(Suppl 12):S47-52. doi: 10.1097/BOT.0000000000000462.
4
Failures in bipolar fresh osteochondral allograft for the treatment of end-stage knee osteoarthritis.双极新鲜骨软骨移植治疗终末期膝骨关节炎的失败情况。
Knee Surg Sports Traumatol Arthrosc. 2015 Jul;23(7):2081-9. doi: 10.1007/s00167-014-2961-1. Epub 2014 Apr 4.
5
You can do arthroplasty in a young patient, but...: Commentary on articles by John P. Meehan, MD, et al.: "Younger age is associated with a higher risk of early periprosthetic joint infection and aseptic mechanical failure after total knee arthroplasty," and Vinay K. Aggarwal, et al.: "Revision total knee arthroplasty in the young patient: is there trouble on the horizon?".你可以在年轻患者身上进行关节成形术,但是……:对医学博士约翰·P·米汉等人所著文章的评论:“全膝关节置换术后,年轻患者早期假体周围关节感染和无菌性机械性失败的风险更高”,以及维奈·K·阿加瓦尔等人所著文章:“年轻患者的全膝关节置换翻修术:即将出现问题吗?”
J Bone Joint Surg Am. 2014 Apr 2;96(7):e58. doi: 10.2106/JBJS.M.01596.
6
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J Am Acad Orthop Surg. 2014 Feb;22(2):121-33. doi: 10.5435/JAAOS-22-02-121.
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Arch Orthop Trauma Surg. 2013 Jan;133(1):87-93. doi: 10.1007/s00402-012-1621-5. Epub 2012 Oct 16.
8
The use of osteochondral allografts in the management of cartilage defects.同种异体骨软骨移植在软骨缺损治疗中的应用。
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