Krettek C, Clausen J-D, Neunaber C
Unfallchirurgische Klinik, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Unfallchirurgische Klinik, Labor für Muskulo-Skelettales Trauma & Regenerative Therapien, Medizinische Hochschule Hannover (MHH), Hannover, Deutschland.
Unfallchirurg. 2017 Nov;120(11):950-960. doi: 10.1007/s00113-017-0429-8.
Cartilage defects in adult patients are so far incurable. Fresh osteochondral allograft (OCA) transplantation is based on the insertion of mature, living, mechanically sound hyaline cartilage into an osteochondral defect where it undergoes osseointegration. Intact hyaline cartilage of OCA does not cause immune reactions in the recipient. Many reports show that small OCA have good osseointegration and show good long-term results. These observations have been incorporated into the development of the fresh large (> 10 cm) osteochondral shell allograft transplantation (FLOCSAT) concept, which is based on the following principles: 1) the thickness of the osseous layer should be kept as thin as possible (target < 6-8 mm) so that the transplant remains stable and fixable. This results in reduced segments of vascularization, simplified ossification and reduced immunogenic bone volume. 2) The bone surface is processed and enlarged (oscillating saw: pie crust technique, drill holes) and areas of sclerosis are simultaneously broken off. 3) Cell reduction and washing out of the bony layer with a pulsatile jet lavage. 4) Prevention of impaction and dessication: cartilage with its living chondrocytes are very sensitive to mechanical contusion and dessication. When introducing the transplant, the tissue must therefore be continually moistened and the pressure acting on the cartilage must be controlled. 5) Stable fixation: extensive uniplanar osteochondral transplants cannot be inserted by the press-fit method; therefore, fixation is carried out with small implants. In this publication we demonstrate how severe and complex posttraumatic or degenerative delayed problems can be solved using FLOCSAT.
目前,成年患者的软骨缺损无法治愈。新鲜骨软骨异体移植(OCA)是将成熟、有活力且力学性能良好的透明软骨植入骨软骨缺损处,使其发生骨整合。OCA完整的透明软骨不会在受者体内引发免疫反应。许多报告显示,小型OCA具有良好的骨整合效果且长期效果良好。这些观察结果已被纳入新鲜大型(>10厘米)骨软骨壳异体移植(FLOCSAT)概念的发展中,该概念基于以下原则:1)骨层厚度应尽可能保持薄(目标<6 - 8毫米),以便移植体保持稳定且可固定。这会减少血管化节段,简化骨化过程并减少免疫原性骨体积。2)对骨表面进行处理并扩大(摆动锯:酥皮技术、钻孔),同时去除硬化区域。3)通过脉动喷射冲洗减少骨层细胞并冲洗掉骨层。4)防止撞击和干燥:带有活软骨细胞的软骨对机械挫伤和干燥非常敏感。因此,在植入移植体时,组织必须持续保持湿润,并且必须控制作用在软骨上的压力。5)稳定固定:大面积的单平面骨软骨移植体不能通过压配方法植入;因此,使用小型植入物进行固定。在本出版物中,我们展示了如何使用FLOCSAT解决严重且复杂的创伤后或退行性延迟问题。