Mattozzi Carlo, Paolino Giovanni, Salvi Monica, Macaluso Laura, Scarnò Marco, DE Vita Gaetano, Calvieri Stefano, Richetta Antonio G
Unit of Dermatology and Venereology, Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy -
Unit of Dermatology and Venereology, Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
G Ital Dermatol Venereol. 2018 Apr;153(2):155-160. doi: 10.23736/S0392-0488.17.05622-X. Epub 2017 Nov 16.
Psoriasis is a common, inflammatory, chronic, relapsing skin disease. The pathogenesis is multifactorial and it is involved both innate and acquired immunity. Several studies have shown the important role of vitamin D in the pathogenesis of this disorder. In this study we have evaluated a possible correlation between vitamin D and clinical severity of psoriasis calculated using the Psoriasis Area Severity Score (PASI) score.
In this case control study we included 141 Caucasian subjects affected by moderate to severe psoriasis and 62 healthy controls. We have calculated PASI score and serum levels of vitamin D.
Psoriatic patients had significantly lower serum levels of 25(OH)D than healthy controls. Using no parametric Spearman's coefficient test between serum levels of vitamin D and the PASI score we found a statistical significant correlation. However, the statistical significance was not reached analyzing separately the patients with psoriatic arthritis, while it was confirmed for patients without an articular involvement.
The present study confirm that serum levels of vitamin D are significantly lower in psoriatic patients and correlate with the clinical severity of psoriasis; these data suggest that psoriatic patients could be screened for vitamin D insufficiency for a more comprehensive management.
银屑病是一种常见的、炎症性的、慢性复发性皮肤病。其发病机制是多因素的，涉及先天免疫和后天免疫。多项研究表明维生素D在该疾病发病机制中起重要作用。在本研究中，我们评估了维生素D与使用银屑病面积和严重程度指数（PASI）评分计算的银屑病临床严重程度之间的可能相关性。
在这项病例对照研究中，我们纳入了141名患有中度至重度银屑病的白种人受试者和62名健康对照。我们计算了PASI评分和维生素D血清水平。
银屑病患者的25(OH)D血清水平显著低于健康对照。使用维生素D血清水平与PASI评分之间的非参数Spearman系数检验，我们发现了统计学上的显著相关性。然而单独分析银屑病关节炎患者时未达到统计学显著性，而在无关节受累的患者中得到了证实。
本研究证实银屑病患者的维生素D血清水平显著较低，且与银屑病的临床严重程度相关；这些数据表明，为了进行更全面的管理，应对银屑病患者进行维生素D缺乏筛查。
