Extremity Trauma and Regenerative Medicine Task Area, United States Army Institute of Surgical Research, 3698 Chambers Pass, BHT1, Fort Sam Houston, Texas, 78234, USA.
Department of Kinesiology, University of Georgia, Athens, Georgia, USA.
Muscle Nerve. 2018 May;57(5):799-807. doi: 10.1002/mus.26016. Epub 2018 Jan 23.
Volumetric muscle loss (VML) occurs following significant traumatic injury or surgical removal of skeletal muscle, resulting in nonrecoverable loss of tissue and long-term dysfunction. Perhaps less recognized is that VML injuries inherently disrupt the neuromuscular unit, resulting in fiber denervation and presumptive motor unit rearrangement, expansion, and/or loss. To characterize neural dysfunction we quantified motoneuron axotomy, in efforts to understand how this relates to the temporal coordination of neuromuscular and morphological alterations due to injury.
In an established rat tibialis anterior (TA) VML injury model, we examined the motoneuron, skeletal muscle, and maximal isometric torque at 3, 7, 14, and 21 days postinjury.
Significant axotomy of 57-79% of all TA muscle motoneurons was observed through 21 days postinjury, which was coupled with a 45-90% TA maximal torque deficit.
A ∼20% partial ablation of the TA muscle causes disproportionate damage across the motor unit acutely postinjury. Muscle Nerve 57: 799-807, 2018.
容积性肌肉损失（VML）发生在重大创伤或骨骼肌切除后，导致组织不可恢复的损失和长期功能障碍。也许人们较少认识到的是，VML 损伤本质上会破坏神经肌肉单元，导致纤维去神经支配以及推定的运动单位重新排列、扩张和/或丧失。为了描述神经功能障碍，我们量化了运动神经元轴突切断，以努力了解这与由于损伤引起的神经肌肉和形态改变的时间协调性有何关系。
在已建立的大鼠胫骨前肌（TA）容积性肌肉损失损伤模型中，我们在损伤后 3、7、14 和 21 天检查了运动神经元、骨骼肌和最大等长扭矩。
在损伤后 21 天内，观察到所有 TA 肌肉运动神经元的轴突切断率为 57-79%，这与 TA 最大扭矩缺陷率为 45-90%相关。
TA 肌肉的约 20%部分消融会导致损伤后急性运动单位的不成比例损伤。肌肉神经 57：807，2018。
Zotero 插件