TUG1、SPRY4-IT1和HULC作为癌症生存的重要预后生物标志物：一项遵循PRISMA标准的荟萃分析。
TUG1, SPRY4-IT1, and HULC as valuable prognostic biomarkers of survival in cancer: A PRISMA-compliant meta-analysis.
作者信息
Zhong Yucheng, Chen Zhicong, Guo Shuyuan, Liao Xinhui, Xie Haibiao, Zheng Yien, Cai Bin, Huang Peixian, Liu Yuhan, Zhou Qun, Liu Yuchen, Huang Weiren
机构信息
aKey Laboratory of Medical Reprogramming Technology, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen b Department of Urology, Peking University First Hospital, The Institute of Urology, Peking University, National Urological Cancer Centre, Beijing cShantou University Medical College, Shantou, China.
出版信息
Medicine (Baltimore). 2017 Nov;96(46):e8583. doi: 10.1097/MD.0000000000008583.
BACKGROUND
Long noncoding RNAs (LncRNAs) are involved in the development and progression of various cancers. Accumulating evidences indicated that expression of lncRNAs was related to the prognosis of tumors.
METHODS
Here, 3 well-known lncRNAs associated with cancer were gathered to prove the potential role of lncRNAs as novel predictors of survival in human cancer. This meta-analysis collected all eligible studies about TUG1, SPRY4-IT1, and HULC and explored the relationship between lncRNAs expression and lymph node metastasis (LNM) or overall survival (OS). A comprehensive, computerized literature search was undertaken by using PubMed, EMBASE, Cochrane Library, and Web of Science (up to October 10, 2017). Strength of association between 3 lncRNAs and cancer prognosis was assessed by computing the hazard ratios (HR) with its corresponding 95% confidence interval (CI). According to the inclusion and exclusion criteria, respectively, 10, 9, and 7 studies of 3 lncRNAs were included in this meta-analysis.
RESULTS
In the current meta-analysis, it could be concluded that the expression of these 3 lncRNAs in tumor tissues is not a direct evidence of LNM. In general, there was a significant negative correlation between TUG1 levels and OS time (pooled HR 1.54, 95% CI 1.06-2.24), SPRY4-IT1 levels and OS time (pooled HR 2.12, 95% CI 1.58-2.86) and HULC levels and OS time (pooled HR 2.10, 95% CI 1.18-3.73). It could be revealed from the result that high level expression of these 3 lncRNAs might be correlated with a bad prognosis.
CONCLUSIONS
In conclusion, the current meta-analysis demonstrated that TUG1, SPRY4-IT1, and HULC might serve as a moderate predictor of survival in human cancer.
背景
长链非编码RNA（lncRNAs）参与多种癌症的发生和发展。越来越多的证据表明lncRNAs的表达与肿瘤预后相关。
方法
本文收集了3种与癌症相关的著名lncRNAs，以证明lncRNAs作为人类癌症生存新预测指标的潜在作用。该荟萃分析收集了所有关于TUG1、SPRY4-IT1和HULC的符合条件的研究，并探讨lncRNAs表达与淋巴结转移（LNM）或总生存期（OS）之间的关系。通过使用PubMed、EMBASE、Cochrane图书馆和科学网（截至2017年10月10日）进行全面的计算机化文献检索。通过计算风险比（HR）及其相应的95%置信区间（CI）来评估3种lncRNAs与癌症预后之间的关联强度。根据纳入和排除标准，本荟萃分析分别纳入了10项、9项和7项关于3种lncRNAs的研究。
结果
在当前的荟萃分析中，可以得出结论，这3种lncRNAs在肿瘤组织中的表达并非LNM的直接证据。总体而言，TUG1水平与OS时间之间存在显著负相关（合并HR 1.54，95%CI 1.06 - 2.24），SPRY4-IT1水平与OS时间之间存在显著负相关（合并HR 2.12，95%CI 1.58 - 2.86），HULC水平与OS时间之间存在显著负相关（合并HR 2.10，95%CI 1.18 - 3.73）。从结果可以看出，这3种lncRNAs的高水平表达可能与不良预后相关。
结论
总之，当前的荟萃分析表明，TUG1、SPRY4-IT1和HULC可能作为人类癌症生存的中度预测指标。
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