• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Effective treatment of narcolepsy-like symptoms with high-frequency repetitive transcranial magnetic stimulation: A case report.高频重复经颅磁刺激有效治疗发作性睡病样症状：一例报告
Medicine (Baltimore). 2017 Nov;96(46):e8645. doi: 10.1097/MD.0000000000008645.
2
Effects of repetitive transcranial magnetic stimulation over right dorsolateral prefrontal cortex on excessive daytime sleepiness in patients with Parkinson's disease.重复经颅磁刺激右侧背外侧前额叶皮质对帕金森病患者日间过度嗜睡的影响。
Sleep Med. 2022 Dec;100:133-138. doi: 10.1016/j.sleep.2022.08.003. Epub 2022 Aug 11.
3
Effects of repetitive transcranial magnetic stimulation in subjects with sleep disorders.重复经颅磁刺激对睡眠障碍患者的影响。
Sleep Med. 2020 Jul;71:113-121. doi: 10.1016/j.sleep.2020.01.028. Epub 2020 Feb 19.
4
Narcolepsy. Signs, symptoms, differential diagnosis, and management.发作性睡病。体征、症状、鉴别诊断及治疗。
Arch Fam Med. 1998 Sep-Oct;7(5):472-8. doi: 10.1001/archfami.7.5.472.
5
Treatment of narcolepsy.发作性睡病的治疗。
Expert Rev Neurother. 2009 Jun;9(6):897-910. doi: 10.1586/ern.09.29.
6
Narcolepsy: clinical approach to etiology, diagnosis, and treatment.发作性睡病：病因、诊断及治疗的临床方法
Rev Neurol Dis. 2011;8(3-4):e97-106.
7
[Current aspects in the diagnosis and therapy of narcolepsy].发作性睡病诊断与治疗的当前进展
Schweiz Med Wochenschr. 1992 Sep 19;122(38):1385-93.
8
Delayed diagnosis, range of severity, and multiple sleep comorbidities: a clinical and polysomnographic analysis of 100 patients of the innsbruck narcolepsy cohort.延迟诊断、严重程度范围广泛且存在多种睡眠合并症：对因斯布鲁克嗜睡症队列的 100 名患者进行的临床和多导睡眠图分析。
J Clin Sleep Med. 2013 Aug 15;9(8):805-12. doi: 10.5664/jcsm.2926.
9
[Narcolepsy: update on etiology, clinical features and treatment].发作性睡病：病因、临床特征及治疗的最新进展
An Sist Sanit Navar. 2010 May-Aug;33(2):191-201.
10
The clinical spectrum of narcolepsy with cataplexy: a reappraisal.伴猝倒发作的发作性睡病的临床谱：重新评估。
J Sleep Res. 2004 Dec;13(4):395-406. doi: 10.1111/j.1365-2869.2004.00422.x.

引用本文的文献

1
Transcranial Magnetic Stimulation for the Treatment of Pediatric Neurological Disorders.经颅磁刺激治疗小儿神经疾病
Curr Treat Options Neurol. 2019 Nov 13;21(11):58. doi: 10.1007/s11940-019-0600-3.
2
Excessive Daytime Sleepiness in Parkinson's Disease: Clinical Implications and Management.帕金森病患者日间过度嗜睡：临床意义与管理。
Chin Med J (Engl). 2018 Apr 20;131(8):974-981. doi: 10.4103/0366-6999.229889.

本文引用的文献

1
Towards understanding rTMS mechanism of action: Stimulation of the DLPFC causes network-specific increase in functional connectivity.为了理解 rTMS 的作用机制：刺激 DLPFC 会导致网络特异性的功能连接增加。
Neuroimage. 2017 Nov 15;162:289-296. doi: 10.1016/j.neuroimage.2017.09.022. Epub 2017 Sep 12.
2
Neuroimaging of Narcolepsy and Kleine-Levin Syndrome.发作性睡病与克莱恩-莱文综合征的神经影像学
Sleep Med Clin. 2017 Sep;12(3):359-368. doi: 10.1016/j.jsmc.2017.03.021. Epub 2017 Jun 13.
3
Medical comorbidity in narcolepsy: findings from the Burden of Narcolepsy Disease (BOND) study.发作性睡病的医学合并症：发作性睡病疾病负担（BOND）研究的结果
Sleep Med. 2017 May;33:13-18. doi: 10.1016/j.sleep.2016.04.004. Epub 2016 May 12.
4
Clinical and practical considerations in the pharmacologic management of narcolepsy.发作性睡病药物治疗的临床与实际考量
Sleep Med. 2015 Jan;16(1):9-18. doi: 10.1016/j.sleep.2014.10.002. Epub 2014 Oct 16.
5
Is narcolepsy a classical autoimmune disease?发作性睡病是一种典型的自身免疫性疾病吗？
Pharmacol Res. 2015 Feb;92:6-12. doi: 10.1016/j.phrs.2014.10.005. Epub 2014 Oct 29.
6
Complete loss of F-waves during cataplectic attacks in patients with narcolepsy.
Neurology. 2014 Nov 25;83(22):2095-6. doi: 10.1212/WNL.0000000000001031. Epub 2014 Oct 29.
7
Does autoreactivity have a role in narcolepsy?自身反应性在发作性睡病中起作用吗？
Lancet Neurol. 2014 Nov;13(11):1072-1073. doi: 10.1016/S1474-4422(14)70168-1.
8
Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS).重复经颅磁刺激（rTMS）治疗应用的循证指南。
Clin Neurophysiol. 2014 Nov;125(11):2150-2206. doi: 10.1016/j.clinph.2014.05.021. Epub 2014 Jun 5.
9
Dorsolateral prefrontal transcranial magnetic stimulation in patients with major depression locally affects alpha power of REM sleep.外侧前额叶经颅磁刺激对重性抑郁症患者 REM 睡眠的局部影响阿尔法功率。
Front Hum Neurosci. 2013 Aug 2;7:433. doi: 10.3389/fnhum.2013.00433. eCollection 2013.
10
Can transcranial magnetic stimulation be used to evaluate patients with narcolepsy?经颅磁刺激能否用于评估发作性睡病患者？
Neurol Sci. 2013 Aug;34(8):1411-20. doi: 10.1007/s10072-012-1253-0. Epub 2012 Nov 29.

高频重复经颅磁刺激有效治疗发作性睡病样症状：一例报告

Effective treatment of narcolepsy-like symptoms with high-frequency repetitive transcranial magnetic stimulation: A case report.

作者信息

Lai Jian-Bo, Han Mao-Mao, Xu Yi, Hu Shao-Hua

机构信息

aDepartment of Psychiatry, First Affiliated Hospital, Zhejiang University School of Medicine bThe Key Laboratory of Mental Disorder's Management in Zhejiang Province cDepartment of VIP, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Medicine (Baltimore). 2017 Nov;96(46):e8645. doi: 10.1097/MD.0000000000008645.

DOI:10.1097/MD.0000000000008645
PMID:29145290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5704835/
Abstract

RATIONALE

Narcolepsy is a rare sleep disorder with disrupted sleep-architecture. Clinical management of narcolepsy lies dominantly on symptom-driven pharmacotherapy. The treatment role of repetitive transcranial magnetic stimulation (rTMS) for narcolepsy remains unexplored.

PATIENT CONCERNS

In this paper, we present a case of a 14-year-old young girl with excessive daytime sleepiness (EDS), cataplexy and hypnagogic hallucinations.

DIAGNOSES

After excluding other possible medical conditions, this patient was primarily diagnosed with narcolepsy.

INTERVENTIONS

The patient received 25 sessions of high-frequency rTMS over the left dorsolateral prefrontal cortex (DLPFC).

OUTCOMES

The symptoms of EDS and cataplexy significantly improved after rTMS treatment. Meanwhile, her score in the Epworth sleep scale (ESS) also remarkably decreased.

LESSONS

This case indicates that rTMS may be selected as a safe and effective alternative strategy for treating narcolepsy-like symptoms. Well-designed researches are warranted in future investigations on this topic.

摘要

理论依据

发作性睡病是一种罕见的睡眠障碍，睡眠结构紊乱。发作性睡病的临床管理主要依赖于症状驱动的药物治疗。重复经颅磁刺激（rTMS）对发作性睡病的治疗作用仍未得到探索。

患者情况

在本文中，我们报告了一例14岁年轻女孩，有日间过度嗜睡（EDS）、猝倒和入睡前幻觉症状。

诊断

排除其他可能的疾病后，该患者初步诊断为发作性睡病。

干预措施

患者接受了25次针对左侧背外侧前额叶皮质（DLPFC）的高频rTMS治疗。

结果

rTMS治疗后，EDS和猝倒症状明显改善。同时，她的爱泼沃斯思睡量表（ESS）评分也显著降低。

经验教训

该病例表明，rTMS可作为治疗发作性睡病样症状的一种安全有效的替代策略。未来对此主题的研究需要精心设计。