Arango María-Teresa, Kivity Shaye, Shoenfeld Yehuda
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel; Center for Autoimmune Diseases Research - CREA, Universidad del Rosario, Bogota, Colombia; Doctoral Program in Biomedical Sciences, Universidad del Rosario, Bogota, Colombia.
Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel; Rheumatic Disease Unit, Sheba Medical Center, Tel-Hashomer, Israel; The Dr. Pinchas Borenstein Talpiot Medical Leadership Program 2013, Sheba Medical Center, Tel-Hashomer, Israel.
Pharmacol Res. 2015 Feb;92:6-12. doi: 10.1016/j.phrs.2014.10.005. Epub 2014 Oct 29.
Narcolepsy is a neurological disorder characterized by excessive daytime sleepiness. It is caused by the loss of orexin producing neurons in the lateral hypothalamus. Current evidences suggest an autoimmune mediated process causing the specific loss of orexin neurons. The high association of the disease with the HLA DQB1*06:02, as well as the link with environmental factors and are important clues supporting this theory. Recently, the association between the occurrence of the disease and vaccination campaign after the 2009 H1N1 pandemic highlighted the importance to increase the knowledge in the Pandora box of the vaccines. This review discusses the last finding regarding the pathogenesis of the disease and its relationship with the H1N1 vaccines.
发作性睡病是一种以日间过度嗜睡为特征的神经系统疾病。它是由下丘脑外侧产生食欲素的神经元缺失所致。目前的证据表明这是一个自身免疫介导的过程，导致食欲素神经元特异性缺失。该疾病与HLA DQB1*06:02的高度相关性，以及与环境因素的联系，都是支持这一理论的重要线索。最近，2009年甲型H1N1流感大流行后该疾病的发生与疫苗接种运动之间的关联，凸显了增加对疫苗这个潘多拉魔盒相关知识了解的重要性。这篇综述讨论了关于该疾病发病机制及其与甲型H1N1流感疫苗关系的最新研究结果。
