Grant Gavin B, Reef Susan E, Patel Minal, Knapp Jennifer K, Dabbagh Alya
MMWR Morb Mortal Wkly Rep. 2017 Nov 17;66(45):1256-1260. doi: 10.15585/mmwr.mm6645a4.
Although rubella virus infection usually causes a mild fever and rash illness in children and adults, infection during pregnancy, especially during the first trimester, can result in miscarriage, fetal death, stillbirth, or infants with a constellation of congenital malformations known as congenital rubella syndrome (CRS) (1). Rubella is a leading vaccine-preventable cause of birth defects. Preventing these adverse pregnancy outcomes is the focus of rubella vaccination programs. In 2011, the World Health Organization (WHO) updated guidance on the preferred strategy for introduction of rubella-containing vaccine (RCV) into national immunization schedules and recommended an initial vaccination campaign, usually targeting children aged 9 months-14 years (1). The Global Vaccine Action Plan 2011-2020 (GVAP), endorsed by the World Health Assembly in 2012, includes goals to eliminate rubella in at least five of the six WHO regions by 2020 (2). This report updates a previous report (3) and summarizes global progress toward rubella and CRS control and elimination from 2000 to 2016. As of December 2016, 152 (78%) of 194 countries had introduced RCV into the national immunization schedule, representing an increase of 53 countries since 2000, including 20 countries that introduced RCV after 2012.
虽然风疹病毒感染在儿童和成人中通常引起轻度发热和皮疹疾病,但孕期感染,尤其是孕早期感染,可导致流产、胎儿死亡、死产或出现一系列先天性畸形的婴儿,即先天性风疹综合征(CRS)(1)。风疹是可通过疫苗预防的主要出生缺陷病因。预防这些不良妊娠结局是风疹疫苗接种项目的重点。2011年,世界卫生组织(WHO)更新了关于将含风疹疫苗(RCV)引入国家免疫规划首选策略的指南,并建议开展初始疫苗接种运动,通常针对9月龄至14岁的儿童(1)。2012年世界卫生大会认可的《2011 - 2020年全球疫苗行动计划》(GVAP)包括到2020年在世界卫生组织六个区域中的至少五个区域消除风疹的目标(2)。本报告更新了之前的一份报告(3),并总结了2000年至2016年全球在风疹和先天性风疹综合征控制及消除方面取得的进展。截至2016年12月,194个国家中的152个(78%)已将含风疹疫苗引入国家免疫规划,自2000年以来增加了53个国家,包括2012年后引入含风疹疫苗的20个国家。