Frieling T, Enck P, Wienbeck M
Department of Gastroenterology, University of Düsseldorf, F.R. Germany.
Dig Dis Sci. 1989 Feb;34(2):202-5. doi: 10.1007/BF01536051.
We used electroencephalographic methods to evoke and record cerebral responses to electrical stimulation of the rectosigmoid colon in eight healthy male volunteers, 20-40 years old. The stimulus was applied via a probe equipped with bipolar ring electrodes which were attached by suction to the mucosa. The probe was positioned 20 cm above the anus. Cerebral responses were recorded by EEG electrodes. Evoked potentials (EPs) in response to electrical stimulation consisted of a series of successive peaks and troughs in the EEG with good reproducibility within and between subjects. The shape and latencies of the intestinal EPs were comparable to other types of EPs reported before. It is concluded that reproducible EPs can be recorded from the scalp after electrical stimulation of the rectosigmoid. The similarity in appearance of these EPs to those previously reported suggests that visceral afferents were stimulated. The technique may become a useful tool to study visceral nervous connections to the brain in health and disease.
我们采用脑电图方法，对8名年龄在20至40岁之间的健康男性志愿者进行乙状结肠直肠电刺激，以诱发并记录大脑反应。刺激通过配备双极环形电极的探头施加，该电极通过吸力附着于黏膜。探头置于肛门上方20厘米处。大脑反应通过脑电图电极记录。电刺激诱发的电位（EPs）在脑电图中表现为一系列连续的峰谷，在受试者内部和之间具有良好的可重复性。肠道EPs的形状和潜伏期与之前报道的其他类型的EPs相当。得出的结论是，对乙状结肠直肠进行电刺激后，可以从头皮记录到可重复的EPs。这些EPs与先前报道的EPs外观相似，表明内脏传入神经受到了刺激。该技术可能成为研究健康和疾病状态下内脏与大脑神经连接的有用工具。
