Zong Shimin, Zeng Xue, Liu Tianyi, Wan Fangmin, Luo Pan, Xiao Hongjun
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
PLoS One. 2017 Nov 16;12(11):e0188195. doi: 10.1371/journal.pone.0188195. eCollection 2017.
Several case-control studies reported the relationship between single nucleotide polymorphisms (SNPs) in HSP70 genes and noise-induced hearing loss (NIHL). However, their conclusions are conflicting. This meta-analysis aims to identify the association of HSP70 variants and NIHL susceptibility.
A systematical literature search was performed in PubMed, Web of Science, EMBASE, and Wanfang Chinese database. The pooled odds radio (OR), 95% confidence interval (CI) and p value were calculated in fixed- or random-effects model according to the I2 value in the heterogeneity test.
Four articles containing five studies, including 633 cases and 926 controls, were included. Under the allele, homozygote and dominant model, the pooled ORs (95%CI, p-value) of rs1061581 were 1.32 (1.06-1.67, p = 0.019), 1.93 (1.10-3.36, p = 0.021) and 1.455 (1.408-2.019, p = 0.025), respectively. In addition, a significant association was found between rs2227956 in Caucasians and the NIHL susceptibility under all five genetic models. We did not discover evidence sufficient to prove the associations between the other three SNPs (rs1043618, rs2763979 and rs2075800) and the NIHL susceptibility.
This meta-analysis indicated that the two HSP70 variants, rs1061581 and rs2227956, may serve as genetic susceptibility factors for NIHL. Larger scale studies are required to further update the results.
多项病例对照研究报道了热休克蛋白70（HSP70）基因单核苷酸多态性（SNP）与噪声性听力损失（NIHL）之间的关系。然而，他们的结论相互矛盾。本荟萃分析旨在确定HSP70基因变异与NIHL易感性之间的关联。
在PubMed、Web of Science、EMBASE和万方中文数据库中进行了系统的文献检索。根据异质性检验中的I2值，采用固定效应或随机效应模型计算合并比值比（OR）、95%置信区间（CI）和p值。
纳入了4篇文章，包含5项研究，共633例病例和926例对照。在等位基因、纯合子和显性模型下，rs1061581的合并OR值（95%CI，p值）分别为1.32（1.06 - 1.67，p = 0.019）、1.93（1.10 - 3.36，p = 0.021）和1.455（1.408 - 2.019，p = 0.025）。此外，在所有五种遗传模型下，发现白种人中rs2227956与NIHL易感性之间存在显著关联。我们未发现足以证明其他三个SNP（rs1043618、rs2763979和rs2075800）与NIHL易感性之间存在关联的证据。
本荟萃分析表明，HSP70的两个变异体rs1061581和rs2227956可能是NIHL的遗传易感因素。需要更大规模的研究来进一步更新结果。
