台湾地区热休克蛋白遗传多态性与年龄相关性听力损伤的相关性。
The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan.
机构信息
Department of Otorhinolaryngology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Otorhinolaryngology, Kaohsiung Municipal Siaogang Hospital, Kaohsiung, Taiwan.
出版信息
J Otolaryngol Head Neck Surg. 2021 Apr 29;50(1):31. doi: 10.1186/s40463-021-00512-2.
BACKGROUND
Age-related hearing impairment (ARHI) is a major disability among the elderly population. Heat shock proteins (HSPs) were found to be associated with ARHI in animal studies. The aim of this study was to analyze the associations of single nucleotide polymorphisms (SNPs) of HSP genes with ARHI in an elderly population in Taiwan.
METHODS
Participants ≥65 years of age were recruited for audiometric tests and genetic analyses. The pure tone average (PTA) of the better hearing ear was calculated for ARHI evaluation. The associations of HSPA1L (rs2075800 and rs2227956), HSPA1A (rs1043618) and HSPA1B (rs2763979) with ARHI were analyzed in 146 ARHI-susceptible (cases) and 146 ARHI-resistant (controls) participants.
RESULTS
The "T" allele of HSPA1B rs2763979 showed a decreased risk of ARHI. The "TT" genotype of rs2763979 also showed a decreased risk of ARHI in the dominant hereditary model. For HSPA1L (rs2075800 and rs2227956) and HSPA1A (rs1043618), the haplotype "CAG" was related to a decreased risk of ARHI.
CONCLUSION
These findings suggest that HSP70 polymorphisms are associated with susceptibility to ARHI in the elderly population.
背景
年龄相关性听力损失（ARHI）是老年人的主要残疾之一。在动物研究中发现热休克蛋白（HSPs）与 ARHI 有关。本研究旨在分析 HSP 基因单核苷酸多态性（SNPs）与台湾老年人群中 ARHI 的相关性。
方法
招募≥65 岁的参与者进行听力测试和基因分析。使用较好耳的纯音平均（PTA）评估 ARHI。分析 HSPA1L（rs2075800 和 rs2227956）、HSPA1A（rs1043618）和 HSPA1B（rs2763979）与 146 名 ARHI 易感（病例）和 146 名 ARHI 抗性（对照）参与者之间的相关性。
结果
HSPA1B rs2763979 的“T”等位基因显示出 ARHI 的风险降低。rs2763979 的“TT”基因型在显性遗传模型中也显示出 ARHI 的风险降低。对于 HSPA1L（rs2075800 和 rs2227956）和 HSPA1A（rs1043618），“CAG”单倍型与 ARHI 的风险降低有关。
结论
这些发现表明 HSP70 多态性与老年人群中 ARHI 的易感性有关。
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