热休克蛋白70-2（HSP70-2）基因多态性与肥胖的关联
Association of heat shock protein70-2 (HSP70-2) gene polymorphism with obesity.
作者信息
Mardan-Nik Maryam, Pasdar Alireza, Jamialahmadi Khadijeh, Avan Amir, Mohebati Mohsen, Esmaily Habibollah, Biabangard-Zak Atefeh, Afzal Javan Fahimeh, Rivandi Mahdi, Ferns Gordon A, Ghayour-Mobarhan Majid
机构信息
a Cardiovascular Research Center, School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
b Department of Modern Sciences and Technologies , School of Medicine, Mashhad University of Medical Sciences , Mashhad , Iran.
出版信息
Ann Hum Biol. 2016 Nov;43(6):542-546. doi: 10.3109/03014460.2015.1119309. Epub 2016 Feb 10.
BACKGROUND
Obesity is a major risk factor of chronic-diseases, including cardiovascular-diseases (CVD). Increasing evidence is showing the association of heat-shock protein (HSP) with type-2 diabetes and CVD; however, there is little data on the relationship between the genetic-polymorphisms of HSP70-2 with obesity.
AIM
The present study has investigated the association between 1267HSP70-2 genetic polymorphism and obesity in an Iranian population with 317 subjects.
SUBJECTS AND METHODS
Anthropometric parameters and biochemical measurements were measured in all the samples, while genotypes were determined using PCR-RFLP. Univariate/multivariate analyses were conducted to explore the relationship between the genetic-polymorphisms and obesity.
RESULTS
The data showed a significant association between 1267HSP70-2 polymorphism in obese subjects, compared to the non-obese group. Moreover, it was observed that this polymorphism was associated with obesity in the CAD + group, which had a high BMI compared to non-obese controls.
CONCLUSION
The 1267HSP70-2 polymorphism is associated with obesity in an Iranian population, supporting a possible potential genetic link between obesity and cardiovascular diseases.
背景
肥胖是包括心血管疾病（CVD）在内的慢性疾病的主要风险因素。越来越多的证据表明热休克蛋白（HSP）与2型糖尿病和心血管疾病有关；然而，关于HSP70-2基因多态性与肥胖之间关系的数据很少。
目的
本研究调查了1267HSP70-2基因多态性与317名伊朗人群肥胖之间的关联。
对象与方法
对所有样本进行人体测量参数和生化检测，同时采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）法确定基因型。进行单因素/多因素分析以探讨基因多态性与肥胖之间的关系。
结果
数据显示，与非肥胖组相比，肥胖受试者中1267HSP70-2多态性存在显著关联。此外，观察到该多态性与CAD +组的肥胖有关，与非肥胖对照组相比，该组体重指数（BMI）较高。
结论
1267HSP70-2多态性与伊朗人群的肥胖有关，支持肥胖与心血管疾病之间可能存在潜在的遗传联系。
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