Lancina Michael G, Yang Hu
Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA 23284, United States.
Department of Chemical & Life Science Engineering, Virginia Commonwealth University, Richmond, VA 23219, United States.
Can J Chem. 2017 Sep;95(9):897-902. doi: 10.1139/cjc-2017-0193. Epub 2017 May 11.
Existing methods of administering ocular drugs are limited in either their safety or efficiency. Nanomedicine therapies have the potential to address this deficiency by creating vehicles that can control drug biodistribution. Dendrimers are synthetic polymeric nanoparticles with a unique highly organized branching structure. In recent years, promising results using dendrimer vehicles to deliver ocular drugs through different routes of administration have been reported. In this review, we briefly summarize these results with emphasis on the dendrimer modifications used to target different ocular structures.
现有的眼部给药方法在安全性或有效性方面都存在局限性。纳米医学疗法有潜力通过制造能够控制药物生物分布的载体来解决这一缺陷。树枝状大分子是具有独特高度有序分支结构的合成聚合物纳米颗粒。近年来，已有报道使用树枝状大分子载体通过不同给药途径递送眼部药物取得了有前景的结果。在本综述中，我们简要总结这些结果，重点关注用于靶向不同眼部结构的树枝状大分子修饰。
