Dhull Anubhav, Yu Carson, Wilmoth Alex Hunter, Chen Minjie, Sharma Anjali, Yiu Samuel
Department of Chemistry, Washington State University, Pullman, WA 99164, USA.
Center for Nanomedicine, Wilmer Eye Institute, Department of Ophthalmology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Pharmaceutics. 2023 May 25;15(6):1591. doi: 10.3390/pharmaceutics15061591.
Dendrimers are biocompatible organic nanomaterials with unique physicochemical properties, making them the focus of recent research in drug delivery. The cornea of the human eye presents a challenge for drug transit due to its inherently impenetrable nature, requiring nanocarrier-mediated targeted drug delivery. This review intends to examine recent advancements in the use of dendrimers for corneal drug delivery, including their properties and their potential for treating various ocular diseases. The review will also highlight the benefit of the novel technologies that have been developed and applied in the field, such as corneal targeting, drug release kinetics, treatments for dry eye disease, antibacterial drug delivery, corneal inflammation, and corneal tissue engineering. The review seeks to provide a comprehensive overview of the current state of research in this field, along with the translational developments in the field of dendrimer-based therapeutics and imaging agents and inspire the potential for future developments and translational opportunities in dendrimers based corneal drug delivery.
树枝状大分子是具有独特物理化学性质的生物相容性有机纳米材料，这使其成为近期药物递送研究的焦点。人眼角膜因其固有的难以穿透的特性，给药物转运带来了挑战，需要纳米载体介导的靶向药物递送。本综述旨在探讨树枝状大分子用于角膜药物递送的最新进展，包括其性质以及治疗各种眼部疾病的潜力。该综述还将强调该领域已开发和应用的新技术的优势，如角膜靶向、药物释放动力学、干眼症治疗、抗菌药物递送、角膜炎症以及角膜组织工程。本综述旨在全面概述该领域的研究现状，以及基于树枝状大分子的治疗剂和成像剂领域的转化进展，并激发基于树枝状大分子的角膜药物递送未来发展和转化机会的潜力。
