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HLA-I、CD8和CD4在宫颈癌中的表达及其临床意义

Expression of HLA-I, CD8, and CD4 and Their Clinical Significance in Cervical Cancer.

作者信息

Fan Jiang Tao, Liao Yan, Si Xiao Hui, Geng Xiao Li, Wei Wei, Xie Qing Li

机构信息

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

Department of Pathology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China.

出版信息

World J Oncol. 2011 Feb;2(1):10-15. doi: 10.4021/wjon286w. Epub 2011 Feb 26.

DOI:10.4021/wjon286w
PMID:29147220
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5649883/
Abstract

BACKGROUND

The local tissue immune status may play a role in the progression of cervical cancer. The aim of our study is to examine the expression of HLA-I, CD8 and CD4 in various cervical diseases and investigate their association with cervical cancer.

METHODS

We chose the tissues of cervical cancer, cervical intraepithelial neoplasia (CIN), chronic cervicitis and peri-cancer tissues, and then detected the expression of HLA-I, CD8 and CD4 using SP immunohistochemistry. The associations of the expression of HLA-I, CD8 and CD4 with the clinicopathologic profiles of the patients were analyzed.

RESULTS

The percentage of positive tissue staining of HLA class I antigen in cervical cancer, CIN, chronic cervicitis and peri-cancer tissues were 40%, 95%, 100.0% and 100.0%, respectively. And the percentage of CD8 in various tissues was 35%, 95%, 100% and 100.0%, respectively. The positive tissue staining percentage of CD4 in the tissues above was 45%, 80%, 100% and 100%, respectively. The percentage of positive tissue staining of HLA-I, CD8 and CD4 were significantly lower in tissues of cervical cancer when compared with other tissues (P < 0.01). No correlation between positive tissue staining of HLA-I, CD8, and CD4 and clinicopathologic profiles was observed (P > 0.05). A positive correlation was found between HLA-I and CD8 expression (Spearman's correlation = 0.913, P < 0.001).

CONCLUSIONS

The expression of HLA-I, CD8 and CD4 are down-regulated or deleted in CIN and cervical cancer, and they may play important roles in the development and progression of CIN and cervical cancer.

摘要

背景

局部组织免疫状态可能在宫颈癌进展中发挥作用。本研究旨在检测HLA-I、CD8和CD4在各种宫颈疾病中的表达，并探讨它们与宫颈癌的相关性。

方法

选取宫颈癌、宫颈上皮内瘤变（CIN）、慢性宫颈炎及癌旁组织，采用SP免疫组化法检测HLA-I、CD8和CD4的表达。分析HLA-I、CD8和CD4表达与患者临床病理特征的相关性。

结果

HLA-I类抗原在宫颈癌、CIN、慢性宫颈炎及癌旁组织中的阳性组织染色百分比分别为40%、95%、100.0%和100.0%。各组织中CD8的百分比分别为35%、95%、100%和100.0%。上述组织中CD4的阳性组织染色百分比分别为45%、80%、100%和100%。与其他组织相比，宫颈癌组织中HLA-I、CD8和CD4的阳性组织染色百分比显著降低（P<0.01）。未观察到HLA-I、CD8和CD4的阳性组织染色与临床病理特征之间存在相关性（P>0.05）。发现HLA-I与CD8表达呈正相关（Spearman相关系数=0.913，P<0.001）。

结论

HLA-I、CD8和CD4在CIN和宫颈癌中表达下调或缺失，它们可能在CIN和宫颈癌的发生发展中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50b/5649883/f9408fe451bc/wjon-02-010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50b/5649883/0a2e65c85de5/wjon-02-010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50b/5649883/f02249fb6772/wjon-02-010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50b/5649883/f9408fe451bc/wjon-02-010-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50b/5649883/0a2e65c85de5/wjon-02-010-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50b/5649883/f02249fb6772/wjon-02-010-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e50b/5649883/f9408fe451bc/wjon-02-010-g003.jpg

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