Guo Weilin, Dai Lan, Qiu Lihua
Department of Obstetrics and Gynecology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Shanghai Key Laboratory of Gynecologic Oncology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Front Immunol. 2025 Jun 5;16:1612032. doi: 10.3389/fimmu.2025.1612032. eCollection 2025.
Cervical cancer is the third most common malignancy among Chinese women in both incidence and mortality. Its progression is closely linked to complex interactions among immune cells within the tumor microenvironment (TME). As key components of the immune landscape, different T cell subsets play diverse and dynamic roles in shaping tumor immunity. This review provides a comprehensive overview of the roles of various T cell subsets in the TME of cervical cancer, with a focus on their distribution, functional heterogeneity, dynamic balance, and variations across different pathological subtypes and disease stages. We also highlight the intricate crosstalk between T cells and other immune cells in the TME and discuss recent advances in T cell-related immunotherapies for cervical cancer, including immune checkpoint inhibitors and HPV-targeted vaccines. By elucidating the roles of distinct T cell subsets and relevant immunotherapeutic approaches within the TME, this review provides insights into potential therapeutic targets and approaches for improving cervical cancer treatment and patient outcome.
宫颈癌是中国女性中发病率和死亡率均位列第三的常见恶性肿瘤。其进展与肿瘤微环境（TME）内免疫细胞之间的复杂相互作用密切相关。作为免疫格局的关键组成部分，不同的T细胞亚群在塑造肿瘤免疫方面发挥着多样且动态的作用。本综述全面概述了各种T细胞亚群在宫颈癌TME中的作用，重点关注它们的分布、功能异质性、动态平衡以及在不同病理亚型和疾病阶段的变化。我们还强调了TME中T细胞与其他免疫细胞之间的复杂相互作用，并讨论了宫颈癌T细胞相关免疫疗法的最新进展，包括免疫检查点抑制剂和HPV靶向疫苗。通过阐明TME中不同T细胞亚群的作用及相关免疫治疗方法，本综述为改善宫颈癌治疗和患者预后的潜在治疗靶点及方法提供了见解。
