Hameed Ammar, White Bob, Chinegwundoh Frank, Thwaini Ali, Pahuja Ajay
Department of Urology, Addenbrookes Hospital, Cambridge, UK.
Teesside University, UK.
World J Oncol. 2011 Jun;2(3):94-101. doi: 10.4021/wjon258w. Epub 2011 Jun 8.
Testicular cancer is one of the few solid cancers that can be cured even when it is metastasized with overall survival rate of more than 90%. The aim of this study was to establish the age adjusted incidence of testicular cancer and to critically assess the management of testicular tumor.
This is a quantitative retrospective study utilizing a review of clinical notes for patients who underwent testicular orchidectomy. The number of cancer cases, types of pathology and cancer staging were examined.
There is no substantial difference between the crude and the age-standardized incidence, moreover no difference from the reported crude incidence by the Scottish intercollegiate guidelines. We found 55.1% of seminoma, 14.28% of non-seminoma and 30.61% of combined (seminoma and non-seminoma), and stage I disease in 61.22% of cases, stage II in 36.73% of cases, and stage IV in 2.04% of cases. Most of the cancers were in the age group 20 - 50 with the majority (48.97%) in the age group 31 - 40. About 42.85% of cases were identified with high tumor markers; higher percentage of seminoma at stage II (40.74%).
There is no substantial difference between the crude and the age-standardized incidence, moreover no difference from the reported crude incidence. Most of the cancers were in the age group 20 - 50 with the majority (48.97%) in the age group 31 - 40. Only 25% of seminomas had elevated tumor markers. Moreover, it is important to re-enforce strict adaptation to the IGCCCG prognostic factor-based classifications.
睾丸癌是少数即使发生转移也能治愈的实体癌之一，其总体生存率超过90%。本研究的目的是确定经年龄调整后的睾丸癌发病率，并严格评估睾丸肿瘤的治疗情况。
这是一项定量回顾性研究，通过查阅接受睾丸切除术患者的临床记录进行。检查了癌症病例数、病理类型和癌症分期。
粗发病率和年龄标准化发病率之间没有实质性差异，而且与苏格兰校际指南报告的粗发病率也没有差异。我们发现精原细胞瘤占55.1%，非精原细胞瘤占14.28%，混合性（精原细胞瘤和非精原细胞瘤）占30.61%，61.22%的病例为I期疾病，36.73%的病例为II期，2.04%的病例为IV期。大多数癌症发生在20至50岁年龄组，其中多数（48.97%）在31至40岁年龄组。约42.85%的病例肿瘤标志物升高；II期精原细胞瘤的比例更高（40.74%）。
粗发病率和年龄标准化发病率之间没有实质性差异，而且与报告 的粗发病率也没有差异。大多数癌症发生在20至50岁年龄组，其中多数（48.97%）在31至40岁年龄组。只有25%的精原细胞瘤肿瘤标志物升高。此外，重要的是要严格遵循基于国际生殖细胞癌协作组（IGCCCG）预后因素的分类。
