McNally Megan E, Carson William
Division of Surgical Oncology, Department of Surgery, The Ohio State University, USA.
World J Oncol. 2012 Apr;3(2):73-77. doi: 10.4021/wjon408w. Epub 2012 Apr 23.
Leptomeningeal carcinomatosis (LC) is a rare and devastating metastatic manifestation of both liquid and solid tumors consisting of dissemination of malignant cells with invasion into the meninges. Few options exist in most clinical situations, especially when LC is the presenting sign of occult malignancy. The prognosis is often poor with limited survival. Aims of palliation must be considered the primary goal for most patients. We report a case in which occult metastatic breast cancer presented with neurological symptoms from LC. We discuss diagnosing the primary malignancy when LC is the presenting manifestation as well as treatment, both palliative and cytoreductive. We also focus on those patients with breast cancer that are at highest risk of developing LC.
柔脑膜癌病（LC）是一种罕见且严重的液体和实体肿瘤转移表现，由恶性细胞播散并侵犯脑膜组成。在大多数临床情况下，治疗选择有限，尤其是当LC是隐匿性恶性肿瘤的首发症状时。预后通常较差，生存期有限。姑息治疗的目标必须被视为大多数患者的主要目标。我们报告一例隐匿性转移性乳腺癌以柔脑膜癌病的神经系统症状为表现的病例。我们讨论当柔脑膜癌病为首发表现时原发性恶性肿瘤的诊断以及姑息治疗和减瘤治疗。我们还关注那些发生柔脑膜癌病风险最高的乳腺癌患者。
