Goel Gaurav
Department of Internal Medicine, Montefiore Medical Center, 600 E 233rd Street, Bronx, New York, 10470, USA. Email:
World J Oncol. 2012 Jun;3(3):124-126. doi: 10.4021/wjon469w. Epub 2012 Jul 5.
Gastrointestinal tract cancers are highly lethal malignancies with early metastatic dissemination. Chemotherapy is therefore of crucial importance in advanced cancer for obtaining palliation of symptoms and improving survival. However, there is no universal standard chemotherapy regimen for the treatment of gastroesophageal cancer. Also, complete remission is an uncommon outcome in advanced gastroesophageal cancers treated with chemotherapy; and where encountered, the response is not sustained. We present a 65 year-old patient who presented with advanced gastric adenocarcinoma. She had histopathologically proven liver metastases. She was treated with chemotherapy comprising of six cycles of Docetaxel, Oxaliplatin and Capecitabine (DOX). She showed complete remission with disappearance of local as well as liver lesions, and achieved disease free status for 9 months. This is the first known sustained Complete Response in a case of advanced gastric carcinoma with DOX combination regimen.
胃肠道癌症是具有早期转移扩散的高致死性恶性肿瘤。因此，化疗对于晚期癌症缓解症状和提高生存率至关重要。然而，治疗胃食管癌并没有通用的标准化化疗方案。此外，在接受化疗的晚期胃食管癌中，完全缓解并不常见；即便出现完全缓解，缓解也难以持续。我们报告一名65岁患有晚期胃腺癌的患者。她经组织病理学证实有肝转移。她接受了由六个周期的多西他赛、奥沙利铂和卡培他滨（DOX）组成的化疗。她实现了完全缓解，局部及肝脏病灶消失，并获得了9个月的无病状态。这是首例已知的采用DOX联合方案治疗晚期胃癌获得持续完全缓解的病例。
