Gonda Kenji, Shibata Masahiko, Shimura Tatsuo, Machida Takeshi, Suzuki Satoshi, Nakamura Izumi, Ohki Shinji, Sakurai Kenichi, Ohto Hitoshi, Tomita Ryouichi, Takenoshita Seiichi
Department of Blood Transfusion and Transplantation Immunology, Fukushima Medical University, 1Hikarigaoka, Fukushima, Fukushima 960-1295, Japan.
Department of Organ Regulatory Surgery, Fukushima Medical University, 1Hikarigaoka, Fukushima, Fukushima 960-1295, Japan.
World J Oncol. 2012 Aug;3(4):158-164. doi: 10.4021/wjon548e. Epub 2012 Aug 26.
Soluble IL-2 receptor (sIL-2R) is the circulating form of a membrane receptor localized on lymphoid and some tumor cells; its biological function is not completely understood.
Serum levels of sIL-2R in blood samples taken from 51 cancer patients (21 gastric and 30 colorectal) and 18 healthy volunteers were measured and found to be significantly higher in the patients.
Concentrations were significantly inversely correlated to nutritional parameters, including total protein and short turnover proteins such as prealbumin, retinol binding protein and transferrin, as well as to the stimulation index, which is a classical parameter of cell-mediated immunity. Concentrations were significantly positively correlated to neutrophil count and inversely to lymphocyte count. Significantly elevated levels of circulating myeloid-derived suppressor cells (MDSCs) were found in patients; this was significantly correlated to sIL-2R levels.
Increased production of sIL-2R correlated with systemic inflammation, nutritional impairment and inhibition of cell-mediated immunity, and thus may be involved in immunological mechanisms inducing cancer cachexia. The same factors also appear to relate closely to induction of MDSCs.
可溶性白细胞介素-2受体（sIL-2R）是一种位于淋巴细胞和某些肿瘤细胞上的膜受体的循环形式；其生物学功能尚未完全明确。
检测了51例癌症患者（21例胃癌患者和30例结直肠癌患者）及18名健康志愿者血样中的sIL-2R血清水平，发现患者的该水平显著更高。
浓度与营养参数显著负相关，这些营养参数包括总蛋白以及短周转蛋白，如前白蛋白、视黄醇结合蛋白和转铁蛋白，还与刺激指数显著负相关，刺激指数是细胞介导免疫的一个经典参数。浓度与中性粒细胞计数显著正相关，与淋巴细胞计数显著负相关。在患者中发现循环髓源性抑制细胞（MDSC）水平显著升高；这与sIL-2R水平显著相关。
sIL-2R产生增加与全身炎症、营养损害及细胞介导免疫抑制相关，因此可能参与了诱导癌症恶病质的免疫机制。相同的因素似乎也与MDSC的诱导密切相关。
