Koyuncuer Ali
Department of Pathology, Antakya State Hospital, Hatay, Turkey. Email:
World J Oncol. 2014 Dec;5(5-6):189-195. doi: 10.14740/wjon869w. Epub 2014 Dec 3.
Basal cell carcinomas (BCCs) and squamous cell carcinomas (SCCs) are known as non-melanoma skin cancers (NMSCs), and they account for approximately 90% of all skin cancers. Cyclooxygenase-2 (COX-2) is expressed in NMSC and in premalignant cutaneous lesions (actinic keratosis).
Immunohistochemistry was performed with COX-2 antibodies in skin biopsies (paraffin tissue archival blocks) from 28 cases with SCC and 33 cases with BCC.
COX-2 was immunostained in a total of 61 cases. There was no staining or weakly positive staining in 73.8% of the cases (45 cases), and there was moderate or strong positive staining in 26.3% of the cases (16 cases). COX-2 was expressed in 42.4% of the BCC cases and in 57.1% of the SCC cases. There was a significant relationship between positive COX-2 staining and SCC (P = 0.016).
In this study, SCCs were significantly correlated with the expression of COX-2. In addition, COX-2 was more frequently expressed in SCC than in BCC. The largest diameters of the SCC were significantly correlated with the expression of COX-2. There were no significant associations between COX-2 staining and clinicopathologic features such as the ulceration of the tumor, its anatomic localization, patient gender, the histologic grade of the SCC and the morphological subtype of the BCC.
基底细胞癌（BCC）和鳞状细胞癌（SCC）被称为非黑色素瘤皮肤癌（NMSC），它们约占所有皮肤癌的90%。环氧化酶-2（COX-2）在NMSC和癌前皮肤病变（光化性角化病）中表达。
使用COX-2抗体对28例SCC和33例BCC患者的皮肤活检标本（石蜡组织存档块）进行免疫组织化学检测。
总共61例标本检测到COX-2免疫染色。73.8%的病例（45例）无染色或弱阳性染色，26.3%的病例（16例）呈中度或强阳性染色。COX-2在42.4%的BCC病例和57.1%的SCC病例中表达。COX-2阳性染色与SCC之间存在显著相关性（P = 0.016）。
在本研究中，SCC与COX-2的表达显著相关。此外，COX-2在SCC中的表达比在BCC中更频繁。SCC的最大直径与COX-2的表达显著相关。COX-2染色与肿瘤溃疡、解剖定位、患者性别、SCC的组织学分级和BCC的形态学亚型等临床病理特征之间无显著关联。
