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交感神经切断加速糖尿病小鼠创面收缩，但抑制再上皮化和周细胞增殖。

Sympathetic Denervation Accelerates Wound Contraction but Inhibits Reepithelialization and Pericyte Proliferation in Diabetic Mice.

机构信息

The Graduate School of Southern Medical University, Guangzhou, China.

Department of Plastic Surgery, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, China.

出版信息

J Diabetes Res. 2017;2017:7614685. doi: 10.1155/2017/7614685. Epub 2017 Sep 24.

DOI:10.1155/2017/7614685
PMID:29147666
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5632918/
Abstract

Previous studies focused on the effects of sympathetic denervation with 6-hydroxydopamine (6-OHDA) on nondiabetic wounds, but the effects of 6-OHDA on diabetic wounds have not been previously reported. In this study, treated mice received intraperitoneal 6-OHDA, and control mice received intraperitoneal injections of normal saline. Full-thickness wounds were established on the backs of mice. The wounds were sectioned (four mice per group) for analysis at 2, 5, 7, 10, 14, 17, and 21 days after injury. The wound areas in the control group were larger than those in the treatment group. Histological scores for epidermal and dermal regeneration were reduced in the 6-OHDA-treated group on day 21. The mast cells (MCs) in each field decreased after sympathectomy on days 17 and 21. The expression levels of norepinephrine, epidermal growth factor (EGF), interleukin-1 beta, NG2 proteoglycan, and desmin in the treatment group were less than those in the control group. In conclusion, 6-OHDA delays reepithelialization during wound healing in diabetic mice by decreasing EGF, but increases wound contraction by reducing IL-1 levels and the number of MCs. Besides, 6-OHDA led to reduced pericyte proliferation in diabetic wounds, which might explain the vascular dysfunction after sympathetic nerve loss in diabetic wounds.

摘要

先前的研究集中于去甲肾上腺素（6-OHDA）对非糖尿病伤口的交感神经切断作用，但 6-OHDA 对糖尿病伤口的影响尚未报道。在这项研究中，实验组小鼠接受腹腔内注射 6-OHDA，对照组小鼠接受腹腔内注射生理盐水。在小鼠背部建立全层伤口。在损伤后 2、5、7、10、14、17 和 21 天，每组 4 只小鼠对伤口进行切片分析。对照组的伤口面积大于治疗组。在第 21 天，治疗组表皮和真皮再生的组织学评分降低。在第 17 和 21 天交感神经切除后，每个视野中的肥大细胞（MC）减少。治疗组的去甲肾上腺素、表皮生长因子（EGF）、白细胞介素-1β、NG2 蛋白聚糖和结蛋白的表达水平低于对照组。总之，6-OHDA 通过降低 EGF 来延迟糖尿病小鼠伤口愈合中的再上皮化，但通过降低 IL-1 水平和 MC 数量来增加伤口收缩。此外，6-OHDA 导致糖尿病伤口中周细胞增殖减少，这可能解释了糖尿病伤口中交感神经丧失后的血管功能障碍。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e5/5632918/bd362525cb0a/JDR2017-7614685.010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31e5/5632918/9bbe513c0b4d/JDR2017-7614685.001.jpg
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