Vilborg Anna, Passarelli Maria C, Steitz Joan A
Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA.
Receptors Clin Investig. 2016;3(1). doi: 10.14800/rci.1169. Epub 2016 Feb 1.
The calcium ion (Ca) is a key intracellular signaling molecule with far-reaching effects on many cellular processes. One of the most important such Ca regulated processes is transcription. A body of literature describes the effect of Ca signaling on transcription initiation as occurring mainly through activation of gene-specific transcription factors by Ca-induced signaling cascades. However, the reach of Ca extends far beyond the first step of transcription. In fact, Ca can regulate all phases of transcription, with additional effects on transcription-associated events such as alternative splicing. Importantly, Ca signaling mediates reduced transcription termination in response to certain stress conditions. This reduction allows readthrough transcription, generating a highly inducible and diverse class of downstream of gene containing transcripts (DoGs) that we have recently described.
钙离子（Ca）是一种关键的细胞内信号分子，对许多细胞过程具有深远影响。Ca调节的最重要过程之一是转录。大量文献描述了Ca信号对转录起始的影响，主要是通过Ca诱导的信号级联激活基因特异性转录因子来实现的。然而，Ca的作用范围远远超出转录的第一步。事实上，Ca可以调节转录的所有阶段，并对诸如可变剪接等转录相关事件产生额外影响。重要的是，Ca信号在响应某些应激条件时介导转录终止减少。这种减少允许通读转录，产生我们最近描述的一类高度可诱导且多样的基因下游含转录本（DoGs）。
