Kayacan Mehmet C, Baykal Yakup B, Karaaslan Tamer, Özsoy Koray, Alaca İlker, Duman Burhan, Delikanlı Yunus E
1 Department of Mechanical Engineering, University of Suleyman Demirel, Isparta - Turkey.
2 Department of Orthopedics and Traumatology, University of Suleyman Demirel, Isparta - Turkey.
J Appl Biomater Funct Mater. 2018 Apr;16(2):68-75. doi: 10.5301/jabfm.5000385.
This study investigated the design and osseointegration process of transitive porous implants that can be used in humans and all trabecular and compact bone structure animals. The aim was to find a way of forming a strong and durable tissue bond on the bone-implant interface.
Massive and transitive porous implants were produced on a direct metal laser sintering machine, surgically implanted into the skulls of sheep and kept in place for 12 weeks. At the end of the 12-week period, the Massive and porous implants removed from the sheep were investigated by scanning electron microscopy (SEM) to monitor the osseointegration process.
In the literature, each study has selected standard sizes for pore diameter in the structures they use. However, none of these involved transitional porous structures. In this study, as opposed to standard pores, there were spherical or elliptical pores at the micro level, development channels and an inner region. Bone cells developed in the inner region. Transitive pores grown gradually in accordance with the natural structure of the bone were modeled in the inner region for cells to develop. Due to this structure, a strong and durable tissue bond could be formed at the bone-implant interface.
Osseointegration processes of Massive vs. porous implants were compared. It was observed that cells were concentrated on the surface of Massive implants. Therefore, osseointegration between implant and bone was less than that of porous implants. In transitive porous implants, as opposed to Massive implants, an outer region was formed in the bone-implant interface that allowed tissue development.
本研究调查了可用于人类以及所有小梁骨和密质骨结构动物的过渡性多孔植入物的设计和骨整合过程。目的是找到一种在骨-植入物界面形成牢固且持久组织结合的方法。
在直接金属激光烧结机上制作块状和过渡性多孔植入物，通过手术植入绵羊颅骨并保持12周。在12周结束时，对从绵羊身上取出的块状和多孔植入物进行扫描电子显微镜（SEM）检查，以监测骨整合过程。
在文献中，每项研究都为其使用的结构选择了标准孔径尺寸。然而，这些研究均未涉及过渡性多孔结构。在本研究中，与标准孔不同，微观层面存在球形或椭圆形孔、发育通道和内部区域。骨细胞在内部区域发育。在内部区域模拟了根据骨的自然结构逐渐生长的过渡性孔，以供细胞发育。由于这种结构，可在骨-植入物界面形成牢固且持久的组织结合。
比较了块状植入物与多孔植入物的骨整合过程。观察到细胞集中在块状植入物表面。因此，植入物与骨之间的骨整合低于多孔植入物。与块状植入物不同，在过渡性多孔植入物的骨-植入物界面形成了一个允许组织发育的外部区域。
