Department of Biomedical Engineering, National Cheng Kung University, Tainan, Taiwan.
Department of Technology Development, Hung Chun Bio-Science Company, Kaohsiung Science Park, Luzhu, Kaohsiung, Taiwan.
PLoS One. 2017 Nov 17;12(11):e0188364. doi: 10.1371/journal.pone.0188364. eCollection 2017.
The success of many endosseous implants in orthopaedic and dental applications depends on the surface characteristics, as they affect osseous integration. Previous investigations indicated that a novel large-grit sand-blasted and acid-etched (SLA) titanium (denoted as SLAffinity-Ti) implant had better bone integration than that of a comparably shaped implant with a plasma-sprayed titanium surface. The purpose of the present investigation was to create a SLAffinity surface on pedicle screws and trauma screws and to compare it with the surfaces of a sand-blasted-only implant and commercial implants in terms of bone integration. The cortical bone and spine of twelve minipigs were implanted with 3 and 4 implants, respectively, and the bone integration was evaluated using micro-computed tomography (micro-CT), mechanical tests (pull-out strength and stripping torque), and histological analysis (toluidine blue and hematoxylin and eosin staining) one and three months after implantation. The micro-CT images showed that the gap between the bone and implant was consistently higher in the sand-blasted-only and commercial groups compared to that in the SLAffinity group 1 and 3 months after implantation. Moreover, the bone volume of implant inserted into bone and the percentage of implant inside bone tissue were greater in the SLAffinity screws 1 and 3 months after implantation, as compared to the sand-blasted and commercial screws. In the mechanical tests, the removal torque and pull-out strength (p < 0.05) were higher in the SLAffinity group at 1 and 3 months. The histological results were consistent with mechanical testing, showing that the SLAffinity group had the most mineralized matrix, the most bone formation around the screws, and the most bone cells in bone tissue. These findings indicate that a SLAffinity surface can effectively enhance the holding strength and integration of pedicle screws and cortical screws, promoting early healing and improving outcomes, compared to sand-blasted-only and commercial implants.
许多骨科和牙科应用中的骨内植入物的成功取决于表面特性，因为它们会影响骨质整合。先前的研究表明，一种新型大粒度喷砂酸蚀（SLA）钛（称为 SLAffinity-Ti）植入物比具有等离子喷涂钛表面的形状相似的植入物具有更好的骨整合。本研究的目的是在椎弓根螺钉和创伤螺钉上制造 SLAffinity 表面，并将其与喷砂处理的植入物和商业植入物的表面在骨整合方面进行比较。十二只小型猪的皮质骨和脊柱分别植入了 3 个和 4 个植入物，分别在植入后 1 个月和 3 个月，使用微计算机断层扫描（micro-CT）、机械测试（拔出强度和剥离扭矩）和组织学分析（甲苯胺蓝和苏木精-伊红染色）评估骨整合。micro-CT 图像显示，在植入后 1 个月和 3 个月，喷砂处理组和商业组的骨与植入物之间的间隙始终高于 SLAffinity 组。此外，在植入后 1 个月和 3 个月，SLAffinity 螺钉的骨内植入物骨体积和骨组织内植入物百分比大于喷砂处理和商业螺钉。在机械测试中，SLAffinity 组在植入后 1 个月和 3 个月时的去除扭矩和拔出强度（p <0.05）较高。组织学结果与机械测试一致，表明 SLAffinity 组具有最多的矿化基质、螺钉周围最多的骨形成和骨组织中最多的骨细胞。这些发现表明，与喷砂处理的植入物和商业植入物相比，SLAffinity 表面可以有效增强椎弓根螺钉和皮质螺钉的固位强度和整合，促进早期愈合并改善结果。
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