Chiang Hsi-Jen, Hsu Heng-Jui, Peng Pei-Wen, Wu Ching-Zong, Ou Keng-Liang, Cheng Han-Yi, Walinski Christopher J, Sugiatno Erwan
Graduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 110, Taiwan.
Research Center for Biomedical Devices and Prototyping Production, Taipei Medical University, Taipei 110, Taiwan.
J Biomed Mater Res A. 2016 Feb;104(2):397-405. doi: 10.1002/jbm.a.35577. Epub 2015 Oct 15.
The purpose of the present study was to examine early tissue response and osseointegration in the animal model. The surface morphologies of SLAffinity were characterized using scanning electron microscopy and atomic force microscopy. The microstructures were examined by X-ray diffraction, and hardness was measured by nanoindentation. Moreover, the safety and toxicity properties were evaluated using computer-aided programs and cell cytotoxicity assays. In the animal model, implants were installed in the mandibular canine-premolar area of 12 miniature pigs. Each pig received three implants: machine, sandblasted, large grit, acid-etched, and SLAffinity-treated implants. The results showed that surface treatment did affect bone-to-implant contact (BIC) significantly. At 3 weeks, the SLAffinity-treated implants were found to present significantly higher BIC values than the untreated implants. The SLAffinity treatments enhanced osseointegration significantly, especially at early stages of bone tissue healing. As described above, the results of the present study demonstrate that the SLAffinity treatment is a reliable surface modification method.
本研究的目的是在动物模型中检测早期组织反应和骨结合情况。使用扫描电子显微镜和原子力显微镜对SLAffinity的表面形态进行表征。通过X射线衍射检查微观结构，并通过纳米压痕测量硬度。此外，使用计算机辅助程序和细胞毒性试验评估安全性和毒性特性。在动物模型中，将种植体植入12只小型猪的下颌犬齿-前磨牙区域。每只猪接受三种种植体：机械加工、喷砂、大颗粒、酸蚀和SLAffinity处理的种植体。结果表明，表面处理确实对骨与种植体接触（BIC）有显著影响。在3周时，发现SLAffinity处理的种植体的BIC值明显高于未处理的种植体。SLAffinity处理显著增强了骨结合，尤其是在骨组织愈合的早期阶段。如上所述，本研究结果表明SLAffinity处理是一种可靠的表面改性方法。
