Institute of Medical Sciences, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave, Toronto, ON, M5G 1X8, Canada.
Sci Rep. 2017 Nov 17;7(1):15764. doi: 10.1038/s41598-017-16058-1.
Children who receive inadequate exposure to sunlight have reduced levels of vitamin D, resulting in rickets, a disease that is characterized by bone deformity, stunted growth, and long term pronounced disability. The United Kingdom rickets incidence rates declined from the early 1960's to mid-1990's, after which there was a dramatic increase. The reason for this change is not well understood. Here we show that an important low frequency mode of climate variability, the Atlantic Multidecadal Oscillation (AMO), with a period of ~60-80 years, has an impact on rickets incidence rates in the United Kingdom through changes in sea level pressure, cloud cover and sunshine duration. This research highlights the important role that multidecadal climate variability can play in human morbidity and suggests that future changes in the AMO may modulate rickets incidence rates throughout the United Kingdom.
儿童如果接受的阳光照射不足，体内的维生素 D 水平就会降低，从而导致佝偻病，这是一种以骨骼畸形、生长迟缓以及长期严重残疾为特征的疾病。英国佝偻病的发病率在 20 世纪 60 年代初到 90 年代中期呈下降趋势，此后急剧上升。这种变化的原因尚不清楚。在这里，我们表明，一种重要的低频气候变率模式——大西洋多年代际振荡（AMO），其周期约为 60-80 年，通过海平面气压、云量和日照时间的变化，对英国佝偻病的发病率产生影响。这项研究强调了多年代际气候变率在人类发病率中的重要作用，并表明未来 AMO 的变化可能会调节整个英国佝偻病的发病率。
