Chang Y C, Yao C S
Eur J Immunol. 1979 Jul;9(7):521-5. doi: 10.1002/eji.1830090707.
Macrophage-mediated cytotoxicity in vitro was studied by a tritiated thymidine incorporation inhibition assay as well as by microscopic examination and optical transmitance determination. It was found that macrophages from patients with malignant diseases showed cytotoxic effects on two malignant human cell lines. The cytotoxic activity was more marked in patients who were clinically tumor-free. Some patients with benign diseases and normal subjects also exhibited cytotoxic macrophages. Macrophage-mediated cytotoxicity (MMC) was thus nonspecific in nature. Cell-free exudate from cancer patients did not influence MMC appreciably. The experimental methods and the possible significance of MMC are discussed.
通过氚标记胸腺嘧啶核苷掺入抑制试验以及显微镜检查和光透射率测定，研究了巨噬细胞介导的体外细胞毒性。发现恶性疾病患者的巨噬细胞对两种人类恶性细胞系表现出细胞毒性作用。在临床上无肿瘤的患者中，细胞毒性活性更为明显。一些良性疾病患者和正常受试者也表现出具有细胞毒性的巨噬细胞。因此，巨噬细胞介导的细胞毒性（MMC）本质上是非特异性的。癌症患者的无细胞渗出液对MMC没有明显影响。本文讨论了实验方法以及MMC的可能意义。
