Kjølbæk Louise, Lorenzen Janne K, Larsen Lesli H, Astrup Arne
Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Rolighedsvej 26, 1958 Frederiksberg C, Denmark.
J Nutr Sci. 2017 Sep 19;6:e50. doi: 10.1017/jns.2017.55. eCollection 2017.
The aim of the present study was to investigate the associations between the habitual Ca intake and faecal fat and energy excretion as well as blood lipid profile in free-living normal-weight and overweight individuals. The participants were enrolled for an 8-d period where data from a 7-d diet registration (days 1-7), a 5-d faeces collection (days 3-7), a 2-d urine collection (days 5-7), and anthropometric measurements and a fasting blood sample (day 8) were collected. Analyses showed that dietary Ca intake (g/10 MJ per d) was positively associated with excretion of faecal fat ( = 0·004) and energy ( = 0·031) when adjusted for BMI, age, sex and intake of Ca-containing supplements. However, after adjustment for intake of fibre, the effect of Ca intake disappeared. Nevertheless, total cholesterol (CHOL) and LDL-CHOL concentrations were associated negatively with Ca intake ( -0·62 (95 % CI -0·96, -0·28) mmol/l, < 0·001, and -0·49 (95 % CI -0·78, -0·20) mmol/l, = 0·001, respectively, per 1000 mg/10 MJ per d increase in Ca intake). In conclusion, incorporation of Ca-rich food products in a habitual diet was associated with reduced total CHOL and LDL-CHOL concentrations, which may lower the risk of CVD in the long term.
本研究的目的是调查正常体重和超重的自由生活个体的习惯性钙摄入量与粪便脂肪、能量排泄以及血脂谱之间的关联。参与者参加了一个为期8天的研究,期间收集了7天饮食记录(第1 - 7天)、5天粪便收集(第3 - 7天)、2天尿液收集(第5 - 7天)的数据,以及人体测量数据和空腹血样(第8天)。分析表明,在调整了体重指数、年龄、性别和含钙补充剂摄入量后,膳食钙摄入量(克/10兆焦/天)与粪便脂肪排泄(P = 0.004)和能量排泄(P = 0.031)呈正相关。然而,在调整了纤维摄入量后,钙摄入量的影响消失了。尽管如此,总胆固醇(CHOL)和低密度脂蛋白胆固醇(LDL - CHOL)浓度与钙摄入量呈负相关(钙摄入量每增加1000毫克/1吉焦/天,CHOL降低 - 0.62(95%可信区间 - 0.96, - 0.28)毫摩尔/升,P < 0.001;LDL - CHOL降低 - 0.49(95%可信区间 - 0.78, - 0.20)毫摩尔/升,P = 0.001)。总之,在习惯性饮食中加入富含钙的食品与降低总CHOL和LDL - CHOL浓度有关,这可能会长期降低心血管疾病的风险。