呼肠孤病毒在肠道组织中的生长与存活：L2和S1基因的作用
Growth and survival of reovirus in intestinal tissue: role of the L2 and S1 genes.
作者信息
Bodkin D K, Fields B N
机构信息
Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Masschusetts.
出版信息
J Virol. 1989 Mar;63(3):1188-93. doi: 10.1128/JVI.63.3.1188-1193.1989.
Abstract
Reovirus serotype 1 Lang can be recovered in high titer from the intestines of neonatal mice up to day 8 after peroral inoculation. By contrast, reovirus serotype 3 Dearing cannot be recovered from intestinal tissue past day 4 after peroral inoculation. This difference between the two reoviruses was mapped by using reassortants generated from nonmutagenized laboratory stocks. When the L2 and S1 genes of reovirus serotype 3 Dearing were present in reassortants, the reassortants behaved like serotype 3 Dearing in exhibiting a decreased capacity to be recovered from intestinal tissue. Likewise, viruses which contained the L2 and S2 genes from serotype 1 Lang exhibited an enhanced capacity to grow and survive, which is characteristic of serotype 1 Lang. Thus, the capacity of reovirus to survive in intestinal tissue was determined by the L2 and S1 genes.
摘要
呼肠孤病毒1型朗株在经口接种后直至第8天的新生小鼠肠道中能够以高滴度回收。相比之下，呼肠孤病毒3型迪林株在经口接种后第4天之后无法从肠道组织中回收。通过使用从非诱变实验室毒株产生的重配株来定位这两种呼肠孤病毒之间的这种差异。当呼肠孤病毒3型迪林株的L2和S1基因存在于重配株中时，重配株的表现类似于3型迪林株，从肠道组织中回收的能力下降。同样，含有来自1型朗株的L2和S2基因的病毒表现出增强的生长和存活能力，这是1型朗株的特征。因此，呼肠孤病毒在肠道组织中存活的能力由L2和S1基因决定。
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