Holland J, Spindler K, Horodyski F, Grabau E, Nichol S, VandePol S
Science. 1982 Mar 26;215(4540):1577-85. doi: 10.1126/science.7041255.
RNA viruses show high mutation frequencies partly because of a lack of the proofreading enzymes that assure fidelity of DNA replication. This high mutation frequency is coupled with high rates of replication reflected in rates of RNA genome evolution which can be more than a millionfold greater than the rates of the DNA chromosome evolution of their hosts. There are some disease implications for the DNA-based biosphere of this rapidly evolving RNA biosphere.
RNA病毒显示出高突变频率，部分原因是缺乏确保DNA复制保真度的校对酶。这种高突变频率与高复制率相关，这反映在RNA基因组进化速率上，其进化速率可能比其宿主DNA染色体的进化速率高出一百多万倍。这种快速进化的RNA生物界对基于DNA的生物界有一些疾病方面的影响。
