Pitino A, Squillaci S, Spairani C, Rassu P C, Cosimi M F
Division of Anatomic Pathology, Hospital "San Giacomo", Novi Ligure (AL), Italy.
Division of Anatomic Pathology, Hospital of Vallecamonica, Esine (BS), Italy.
Pathologica. 2017 Sep;109(3):162-167.
Papillary lesions of the breast can be one of the most challenging aspects of mammary pathology because of a wide morphologic spectrum that may be encountered in these lesions. An unusual breast tumor has been first classified as "breast tumor resembling the tall cell variant of papillary thyroid carcinoma" and subsequently renamed "tall cell variant of papillary breast carcinoma". To our knowledge, only 13 cases of this neoplasm have been reported so far. Metastasis to the breast is not an uncommon event and about 5% of all such cases are of the thyroid origin. We report the clinico-pathological and immunohistochemical features, together with a molecular screening for BRAF mutations, of an additional case of tall cell variant of papillary breast carcinoma occurring in a 65-year-old woman. The immunohistochemical and molecular clues leading to the correct diagnosis have been correlated with the data of the literature. Tall cell variant of papillary breast carcinoma represents a unique histologic subtype of mammary carcinoma of probably low malignant potential which has to be recognized to avoid misdiagnosis as metastatic carcinoma from the thyroid.
乳腺乳头状病变可能是乳腺病理学中最具挑战性的方面之一，因为这些病变可能呈现出广泛的形态学谱。一种不常见的乳腺肿瘤最初被归类为“类似甲状腺乳头状癌高细胞变体的乳腺肿瘤”，随后更名为“乳腺乳头状癌高细胞变体”。据我们所知，迄今为止，仅报道了13例这种肿瘤。乳腺转移并不罕见，所有此类病例中约5%起源于甲状腺。我们报告了一名65岁女性发生的另一例乳腺乳头状癌高细胞变体的临床病理、免疫组化特征以及BRAF突变的分子筛查情况。导致正确诊断的免疫组化和分子线索已与文献数据相关联。乳腺乳头状癌高细胞变体代表了一种可能具有低恶性潜能的独特组织学亚型的乳腺癌，必须予以识别以避免误诊为甲状腺转移癌。
