Ibrahim Omer, Wenande Emily, Hogan Sara, Arndt Kenneth A, Haedersdal Merete, Dover Jeffrey S
SkinCare Physicians, Chestnut Hill, Massachusetts, 02467.
Department of Dermatology, University of Copenhagen, Bispebjerg Hospital, Copenhagen, Denmark.
Lasers Surg Med. 2018 Jan;50(1):20-27. doi: 10.1002/lsm.22769. Epub 2017 Nov 20.
The percutaneous penetration of topically applied compounds can be enhanced using external chemical or physical sources and thus laser-assisted drug delivery is a burgeoning area of interest within the field of dermatology.
This article briefly discusses the mechanism of laser-assisted drug delivery and expands upon the challenges and safety issues that may arise in the clinical implementation of this modality.
The existing literature demonstrates that investigators and clinicians in dermatology have successfully delivered anti-inflammatory, anti-neoplastic, and anti-oxidative medications transdermally for the treatment of a variety of conditions including scarring, photoageing, and cutaneous neoplasia. Despite growth of the field, much remains to be learned about the applicability of laser-assisted drug delivery in humans, and practitioners are faced with new safety concerns that may be associated with this treatment modality.
Challenges in laser assisted drug delivery include unpredictability of dosing and response to therapy, possibility of inducing local and systemic reactions, and variability in treatment regimens. Lasers Surg. Med. 50:20-27, 2018. © 2017 Wiley Periodicals, Inc.
通过外部化学或物理源可增强局部应用化合物的经皮渗透，因此激光辅助药物递送是皮肤病学领域中一个新兴的研究热点。
本文简要讨论激光辅助药物递送的机制，并详述在该治疗方式临床应用中可能出现的挑战和安全问题。
现有文献表明，皮肤科的研究人员和临床医生已成功通过透皮方式递送抗炎、抗肿瘤和抗氧化药物，用于治疗多种病症，包括瘢痕形成、光老化和皮肤肿瘤。尽管该领域有所发展，但关于激光辅助药物递送在人体中的适用性仍有许多有待了解之处，从业者面临着可能与此治疗方式相关的新安全问题。
激光辅助药物递送面临的挑战包括给药剂量和治疗反应的不可预测性、诱发局部和全身反应的可能性以及治疗方案的变异性。《激光外科与医学》50:20 - 27, 2018。© 2017威利期刊公司
