Sklar Lindsay R, Burnett Christopher T, Waibel Jill S, Moy Ronald L, Ozog David M
Department of Dermatology, Henry Ford Hospital, 3013 West Grand Blvd, Suite 800, Detroit, Michigan, 48202.
Lasers Surg Med. 2014 Apr;46(4):249-62. doi: 10.1002/lsm.22227. Epub 2014 Mar 24.
Topically applied drugs have a relatively low cutaneous bioavailability.
This article reviews the existing applications of laser assisted drug delivery, a means by which the permeation of topically applied agents can be enhanced into the skin.
The existing literature suggests that lasers are a safe and effective means of enhancing the delivery of topically applied agents through the skin. The types of lasers most commonly studied in regards to drug delivery are the carbon dioxide (CO2 ) and erbium:yttrium-aluminum-garnet (Er:YAG) lasers. Both conventional ablative and fractional ablative modalities have been utilized and are summarized herein.
The majority of the existing studies on laser assisted drug delivery have been performed on animal models and additional human studies are needed.
Laser assisted drug delivery is an evolving technology with potentially broad clinical applications. Multiple studies demonstrate that laser pretreatment of the skin can increase the permeability and depth of penetration of topically applied drug molecules for both local cutaneous and systemic applications.
局部应用的药物经皮生物利用度相对较低。
本文综述激光辅助药物递送的现有应用，这是一种可增强局部应用药物渗透进入皮肤的方法。
现有文献表明，激光是增强局部应用药物经皮递送的一种安全有效的手段。在药物递送方面研究最广泛的激光类型是二氧化碳（CO2）激光和铒：钇铝石榴石（Er:YAG）激光。传统剥脱性和非剥脱性模式均已被采用，并在此进行总结。
现有的大多数关于激光辅助药物递送的研究是在动物模型上进行的，还需要更多人体研究。
激光辅助药物递送是一项不断发展的技术，具有潜在的广泛临床应用前景。多项研究表明，皮肤的激光预处理可增加局部应用药物分子在局部皮肤和全身应用中的渗透性和渗透深度。
