Alegre-Sánchez A, Jiménez-Gómez N, Boixeda P
Unidad de Láser, Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.
Unidad de Láser, Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.
Actas Dermosifiliogr (Engl Ed). 2018 Dec;109(10):858-867. doi: 10.1016/j.ad.2018.07.008. Epub 2018 Sep 25.
Absorption of topical products through the epidermis is limited by the skin's barrier function. Numerous techniques and agents such as microneedling, dermabrasion, radiofrequency, and lasers have been used to increase penetration within an approach known as transdermal drug delivery. One of these techniques is laser-assisted drug delivery (LADD), which often uses ablative fractional lasers (CO or erbium:YAG lasers) because of their capacity to produce microscopic ablated channels. The parameters in LADD need to be adjusted to the patient, the skin condition and its location, and the drug. LADD has been used with various topical products, such as corticosteroids, photosensitizers, and immunotherapy agents (imiquimod or 5-fluorouracil) to treat numerous conditions, including scars, nonmelanoma skin cancer, and photodamage. LADD is a promising technique that enhances the absorption of topical molecules while adding the synergic effect of the laser.
局部用产品通过表皮的吸收受到皮肤屏障功能的限制。诸如微针、磨皮术、射频和激光等众多技术及制剂已被用于在一种称为透皮给药的方法中增加渗透率。这些技术之一是激光辅助给药（LADD），由于其能够产生微小的消融通道，该技术通常使用剥脱性分数激光（CO或铒：钇铝石榴石激光）。LADD中的参数需要根据患者、皮肤状况及其部位以及药物进行调整。LADD已与各种局部用产品联合使用，如皮质类固醇、光敏剂和免疫治疗剂（咪喹莫特或5-氟尿嘧啶），以治疗多种病症，包括疤痕、非黑色素瘤皮肤癌和光损伤。LADD是一种很有前景的技术，它能增强局部分子的吸收，同时增加激光的协同效应。
