Department of Chemistry, Sungkyunkwan University , Suwon, 16419, Korea.
Org Lett. 2017 Dec 1;19(23):6316-6319. doi: 10.1021/acs.orglett.7b03076. Epub 2017 Nov 20.
A highly enantioselective hydrosilylation of ketones was developed for the synthesis of a variety of chiral secondary alcohols. In the presence of a chiral oxazaborolidinium ion (COBI) catalyst, the reaction proceeded with good yields (up to 99%) with excellent enantioselectivities (up to 99% ee).
发展了一种酮的高对映选择性氢化硅烷化反应，用于合成各种手性仲醇。在手性噁唑硼烷离子（COBI）催化剂的存在下，该反应以良好的收率（高达 99%）和优异的对映选择性（高达 99%ee）进行。
