Kim Taehyeong, Jeong Hye-Min, Venkateswarlu Anipireddy, Ryu Do Hyun
Department of Chemistry, Sungkyunkwan University, Suwon 16419, Republic of Korea.
Org Lett. 2020 Jul 2;22(13):5198-5201. doi: 10.1021/acs.orglett.0c01820. Epub 2020 Jun 18.
A highly enantioselective allylation reaction of aldehydes with silyl reagents was developed for the synthesis of a variety of chiral homoallylic alcohols. In the presence of a chiral oxazaborolidinium ion (COBI) catalyst, the reaction proceeded in high yield (up to 99%) with excellent asymmetric induction (up to 99% ee).
开发了一种醛与硅试剂的高度对映选择性烯丙基化反应，用于合成多种手性高烯丙醇。在手性恶唑硼烷鎓离子（COBI）催化剂存在下，该反应以高产率（高达99%）进行，具有优异的不对称诱导效果（高达99% ee）。
