Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Department of Biochemistry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.
Mult Scler Relat Disord. 2018 Jan;19:79-84. doi: 10.1016/j.msard.2017.11.010. Epub 2017 Nov 13.
Environmental factors that are involved in the development of autoimmune diseases include bacteria, viruses, and xenobiotics such as chemicals, drugs, and metals. Regarding the metals, a number of studies have demonstrated that oxidative stress is one of the well-directed pathways of arsenic-induced tissue damages. This study was designed to explore the serum concentrations of arsenic and its correlation with markers associated with oxidative stress in relapsing-remitting MS (RRMS) patients.
This case-controlled study comprised 50 patients with RRMS and 50 healthy subjects. Serum arsenic levels, total antioxidant potential, malondialdehyde (MDA), and lactate levels were measured.
The arsenic value, MDA, and lactate levels were elevated meaningfully while FRAP level significantly was decreased in RRMS patients with respect to healthy subjects (P <0.05). Furthermore, arsenic serum levels were positively correlated with serum concentrations of MDA and lactate. In contrast, serum levels were negatively correlated to FRAP values in RRMS patients.
Taken together, the association between arsenic level and oxidative stress parameters supports the hypothesis that high serum arsenic levels may play a critical role in the pathogenesis of MS progression.
涉及自身免疫性疾病发展的环境因素包括细菌、病毒和外源性化学物质、药物和金属等。关于金属，许多研究表明氧化应激是砷诱导组织损伤的一种明确途径。本研究旨在探讨复发性缓解型多发性硬化症（RRMS）患者血清中砷的浓度及其与氧化应激标志物的相关性。
本病例对照研究包括 50 例 RRMS 患者和 50 名健康对照者。检测血清砷水平、总抗氧化能力、丙二醛（MDA）和乳酸水平。
RRMS 患者的砷值、MDA 和乳酸水平显著升高，而 FRAP 水平显著降低（P<0.05）。此外，RRMS 患者血清砷水平与 MDA 和乳酸浓度呈正相关，与 FRAP 值呈负相关。
综上所述，砷水平与氧化应激参数之间的关联支持这样一种假设，即高血清砷水平可能在 MS 进展的发病机制中起关键作用。
