Huang Rui, Zhao Ying, Wang Ying, Zhou Lei, Chen Yu-Feng, Wang Jin-Feng
a Department of Neurosurgery , Second Hospital of Jilin University , Changchun 130041 , China.
b Department of Hand Surgery , Second Hospital of Jilin University , Changchun 130041 , China.
J Asian Nat Prod Res. 2018 Sep;20(9):860-866. doi: 10.1080/10286020.2017.1399880. Epub 2017 Nov 21.
A chemical investigation of the 70% ethanol extract from the stem bark of Dysoxylum lukii afforded three new ring A-seco triterpenoids, dysoxylukiines A-C (1-3). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC, and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties. Consequently, compound 3 exhibited modest cytotoxic activities against four osteosarcoma cell lines (SOSP-9607, MG-63, Saos-2, and M663) with IC values less than 10 μM.
对吕宋蜜茱萸（Dysoxylum lukii）茎皮70%乙醇提取物进行的化学研究得到了三种新的A环开环三萜类化合物，吕宋蜜茱萸素A-C（1-3）。基于广泛的一维和二维核磁共振（COSY、HMQC、HMBC和NOESY）分析阐明了它们的结构。对分离得到的化合物进行了体外细胞毒性评估。结果，化合物3对四种骨肉瘤细胞系（SOSP-9607、MG-63、Saos-2和M663）表现出适度的细胞毒性活性，其半数抑制浓度（IC）值小于10 μM。
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