Zeydan Burcu, Kantarci Orhun H
Department of Neurology, Mayo Clinic and Foundation, 200 First Street, Southwest, Rochester, MN 55905, USA; Department of Radiology, Mayo Clinic and Foundation, 200 First Street, Southwest, Rochester, MN 55905, USA.
Department of Neurology, Mayo Clinic and Foundation, 200 First Street, Southwest, Rochester, MN 55905, USA.
Neurol Clin. 2018 Feb;36(1):163-171. doi: 10.1016/j.ncl.2017.08.006.
In multiple sclerosis (MS), disease course is defined by a subclinical or clinical relapsing remitting phase, a progressive phase, and the overlapping phase in-between. Each phase can have intermittently active or inactive periods. Subclinical activity in radiologically isolated syndrome evolving to primary-progressive MS is mostly indistinguishable from relapsing-remitting MS evolving to secondary-progressive MS. The onset of progressive-phase MS is age-dependent but time and pre-progressive phase agnostic. Pathologic hallmarks of progressive MS onset also appear to be age-dependent but pre-progressive phase agnostic. Onset of progressive MS is characterized by a peak in smoldering plaques.
在多发性硬化症（MS）中，疾病进程由亚临床或临床复发缓解期、进展期以及两者之间的重叠期来界定。每个阶段都可能有间歇性的活跃期或非活跃期。从放射学孤立综合征发展为原发进展型MS的亚临床活动，与从复发缓解型MS发展为继发进展型MS的情况大多难以区分。进展期MS的发病与年龄相关，但与时间和进展前期无关。进展型MS发病的病理特征似乎也与年龄相关，但与进展前期无关。进展型MS的发病特征是隐匿性斑块达到峰值。
