Muccilli Alexandra, Seyman Estelle, Oh Jiwon
Division of Neurology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada; Division of Neurology, Centre Hospitalier de L'Université de Montréal, Université de Montréal, 1058 Saint-Denis Street, Montreal, Quebec H2X 3J4, Canada.
Division of Neurology, St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, Ontario, M5B 1W8, Canada.
Neurol Clin. 2018 Feb;36(1):35-57. doi: 10.1016/j.ncl.2017.08.009.
Spinal cord (SC) MRI in multiple sclerosis (MS) has significant usefulness in clinical and investigational settings. Conventional MRI of the SC is used in clinical practice, because it has both diagnostic and prognostic value. A number of advanced, quantitative SC MRI measures that assess the structural and functional integrity of the SC have been evaluated in investigational settings. These techniques have collectively demonstrated usefulness in providing insight into microstructural and functional changes relevant to disability in MS. With further development, these techniques may be useful in clinical trial settings as biomarkers of neurodegeneration and protection, and in day-to-day clinical practice.
脊髓（SC）磁共振成像（MRI）在多发性硬化症（MS）的临床和研究环境中具有重要作用。脊髓的传统MRI在临床实践中被使用，因为它具有诊断和预后价值。在研究环境中，已经评估了许多用于评估脊髓结构和功能完整性的先进定量脊髓MRI测量方法。这些技术共同证明了其在深入了解与MS残疾相关的微观结构和功能变化方面的作用。随着进一步发展，这些技术可能在临床试验环境中作为神经退行性变和保护的生物标志物有用，并且在日常临床实践中也有用。
