Webber Troy A, Soder Heather E, Potts Geoffrey F, Bornovalova Marina A
Department of Psychology, University of South Florida, 4202 East Fowler Ave., PCD4118G, Tampa, FL 33620, United States.
Department of Psychology, University of South Florida, 4202 East Fowler Ave., PCD4118G, Tampa, FL 33620, United States.
Biol Psychol. 2018 Feb;132:91-95. doi: 10.1016/j.biopsycho.2017.11.008. Epub 2017 Nov 20.
Reduced relative length of the 2nd to 4th digits (2D:4D) is thought to partially reflect fetal testosterone (FT) exposure, a process suspected to promote relatively permanent effects on the brain and behavior via structural and functional neuroadaptations. We examined the effect of 2D:4D on neural response - assessed by P2a and feedback-related negativity (FRN) event-related potentials (ERPs) - to motivational stimuli (reward or punishment) using two counterbalanced conditions of a passive S1/S2 outcome prediction design. P2a to expected and unexpected delivered rewards or punishments ($1 or white noise burst, respectively) and FRN to withheld rewards or punishments ($0 or silence, respectively) were observed in undergraduates. Lower left 2D:4D and greater 2D:4D predicted amplified P2a to the delivery (but not FRN to the omission) of motivationally salient stimuli, regardless of valence and probability. These preliminary findings suggest that FT may organize dopamine neurons to respond more strongly to the delivery of motivational stimuli.
第二至第四指相对长度降低（2D:4D）被认为部分反映了胎儿期睾酮（FT）暴露情况，这一过程被怀疑通过结构和功能性神经适应对大脑和行为产生相对持久的影响。我们使用被动S1/S2结果预测设计的两种平衡条件，研究了2D:4D对神经反应的影响——通过P2a和反馈相关负波（FRN）事件相关电位（ERP）评估——对动机性刺激（奖励或惩罚）的反应。在本科生中观察到对预期和意外给予的奖励或惩罚（分别为1美元或白噪声爆发）的P2a以及对 withheld奖励或惩罚（分别为0美元或沉默）的FRN。无论效价和概率如何，较低的左2D:4D和较高的2D:4D预测对动机性显著刺激的给予（但不是对遗漏的FRN）会放大P2a。这些初步发现表明，FT可能会组织多巴胺神经元对动机性刺激的给予做出更强的反应。
