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撤稿:长链非编码 RNA 心肌梗死相关转录物(MIAT)通过 miR-93 调控 TLR4 促进心肌肥大。

RETRACTED: LncRNA myocardial infarction-associated transcript (MIAT) contributed to cardiac hypertrophy by regulating TLR4 via miR-93.

机构信息

Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng 475000, China.

Department of Cardiology, Huaihe Hospital of Henan University, Kaifeng 475000, China.

出版信息

Eur J Pharmacol. 2018 Jan 5;818:508-517. doi: 10.1016/j.ejphar.2017.11.031. Epub 2017 Nov 21.

DOI:10.1016/j.ejphar.2017.11.031
PMID:29157986
Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the Editor-in-Chief after concerns were raised about the article on PubPeer (https://pubpeer.com/publications/88E67BAC524E92069B2AA3474D2BB8?utm_source=Chrome&utm_medium=BrowserExtension&utm_campaign=Chrome). In addition the editor found more issues in some Western Blot figures. 1. Bands of figure 1C ANF 30min , 60min, 12h, 24h are identical to those in Fig 4C ANF control, AngII, AngII+si-NC and AngII+si-MAT 2. Beta-actin bands of Fig 1C are identical to those in Fig 4C, but blots represent different experimental conditions/samples. 3. Bands in Fig 6 D AngII and AngII+mir-NC show similarities with these of AngII+mir-93 and AngII+mir93+vector (band shapes and irregularities appear identical) After several attempts to reach out to the corresponding author, no response was provided. The manipulation of images casts doubts on all the data, and accordingly also the conclusions based on that data, in this publication. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

摘要

这篇文章已被撤回

请参阅爱思唯尔的撤稿政策(http://www.elsevier.com/locate/withdrawalpolicy)。在 PubPeer(https://pubpeer.com/publications/88E67BAC524E92069B2AA3474D2BB8?utm_source=Chrome&utm_medium=BrowserExtension&utm_campaign=Chrome)上对该文章提出质疑后,应主编的要求撤回了这篇文章。此外,编辑在一些 Western Blot 图中发现了更多的问题。1. 图 1C ANF 30min、60min、12h、24h 的条带与图 4C ANF 对照物、AngII、AngII+si-NC 和 AngII+si-MAT 中的条带相同。2. 图 1C 的β-肌动蛋白条带与图 4C 中的条带相同,但印迹代表不同的实验条件/样本。3. 图 6 D AngII 和 AngII+mir-NC 的条带与 AngII+mir-93 和 AngII+mir93+vector 的条带相似(条带形状和不规则性看起来相同)。尽管多次尝试联系通讯作者,但均未得到回复。图像的操纵使所有数据都产生了疑问,因此,基于这些数据的结论也在本出版物中受到质疑。因此,本文代表了对科学出版系统的严重滥用。科学界对这一问题持非常强烈的态度,并向该期刊的读者道歉,因为在提交过程中没有发现这一问题。

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