Department of Biochemistry, BK21 Plus and Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 08826, Seoul, Republic of Korea.
Comparative Medicine Disease Research Center, Seoul National University, 08826, Seoul, Republic of Korea.
Heart Fail Rev. 2023 Nov;28(6):1437-1453. doi: 10.1007/s10741-023-10342-1. Epub 2023 Oct 5.
Cardiovascular disease (CVD) has reached epidemic proportions and is a leading cause of death worldwide. One of the long-standing goals of scientists is to repair heart tissue damaged by various forms of CVD such as cardiac hypertrophy, dilated cardiomyopathy, myocardial infarction, heart fibrosis, and genetic and developmental heart defects such as heart valve deformities. Damaged or defective heart tissue has limited regenerative capacity and results in a loss of functioning myocardium. Advances in transcriptomic profiling technology have revealed that long noncoding RNA (lncRNA) is transcribed from what was once considered "junk DNA." It has since been discovered that lncRNAs play a critical role in the pathogenesis of various CVDs and in myocardial regeneration. This review will explore how lncRNAs impact various forms of CVD as well as those involved in cardiomyocyte regeneration. Further, we discuss the potential of lncRNAs as a therapeutic modality for treating CVD.
心血管疾病（CVD）已达到流行程度，是全球范围内的主要死亡原因之一。科学家们的长期目标之一是修复各种形式的 CVD 引起的心脏组织损伤，如心脏肥大、扩张型心肌病、心肌梗死、心脏纤维化以及心脏瓣膜畸形等遗传和发育性心脏缺陷。受损或有缺陷的心脏组织再生能力有限，导致功能心肌丧失。转录组谱分析技术的进步揭示了长非编码 RNA（lncRNA）是从曾经被认为是“垃圾 DNA”的地方转录而来的。此后发现，lncRNA 在各种 CVD 的发病机制以及心肌再生中发挥着关键作用。本综述将探讨 lncRNA 如何影响各种形式的 CVD 以及那些参与心肌细胞再生的 lncRNA。此外，我们还讨论了 lncRNA 作为治疗 CVD 的治疗方法的潜力。
